Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

 

ISAC Approval Date Title
22/08/2018 The role of CA125 in the detection of ovarian cancer in symptomatic primary care patients
22/08/2018 Testosterone replacement therapy and the risk of prostate cancer in men with age-related hypogonadism
09/08/2018 An assessment of CPRD Aurum data quality
09/08/2018 Characterising the renal function of newly diagnosed non-valvular atrial fibrillation patients
07/08/2018 Examining treatment patterns of antidepressant and antipsychotic prescriptions; and serious adverse events and the associated economic cost of antipsychotic drug use in people with dementia
07/08/2018 Relationship between Body Mass Index (BMI) trajectory and the risk of cardiovascular disease and diabetes among overweight and obese people: A UK Primary Care-based cohort study
01/08/2018 A study on the epidemiology of tinnitus in the United Kingdom
01/08/2018 Defining patient groups at short-term high risk of fracture and evaluating current practice of osteoporosis treatment and rate of different fractures and cardiovascular events in these patient groups
01/08/2018 Impact of subsequent major adverse cardiovascular events on mortality in a post-myocardial infarction population: a retrospective UK database analysis
27/07/2018 A study of cardiovscular mortality and morbidity of patients with adrenal insufficiency
24/07/2018 Understanding the impact of the routine use of anti-diabetic (PPAR gamma)/anti-hyperlipidaemic (PPAR alpha) medication on risk of brain tumours and case fatality
23/07/2018 Evaluating effect modification using propensity score matching and disease risk score methods: an empirical study
20/07/2018 Dipeptidyl peptidase-4 inhibitors and the risk of bullous pemphigoid among patients with type 2 diabetes
20/07/2018 Using electronic health records to assess effectiveness of national policy in dementia recognition in the UK
20/07/2018 Serum cholesterol trajectories in the years prior to lymphoma diagnosis
16/07/2018 Risk factors of cardiovascular disease amongst users of anti-osteoporosis therapy/ies, patients with osteoporosis, or those suffering a fracture in the UK NHS: a cohort study
16/07/2018 Predicting risk of dementia using routine electronic health records
16/07/2018 Correlation of forced expiratory volume in one second with mortality and resource use in patients with asthma
12/07/2018 Describing monotherapy and combination use in male and female patients with treatment for Lower Urinary Tract Symptoms. A retrospective, observational study using the UK CPRD
12/07/2018 Drug utilisation among primary care patients with knee osteoarthritis (KOA): a population-based study using CPRD