Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
13/02/2018 Epidemiology of von Willebrand Disease in the UK (1989-2016): Prevalence, treatment patterns, descriptive characteristics, and incidence and prevalence of various outcomes and co-morbidities based on routine clinical care.
13/02/2018 Risk of Serious Infections in Patients with Psoriasis: a Cohort Study using the Clinical Practice Research Datalink
13/02/2018 Determining profiles of musculoskeletal health using electronic health records
08/02/2018 Chronic kidney disease stage G3-G5 and the risk of subsequent fractures after hip fracture
05/02/2018 Aripiprazole and risk of psychiatric treatment failure
24/01/2018 Feasibility study to establish the value of linked CPRD and HES data to support medical device vigilance
22/01/2018 Partner bereavement and subsequent diagnosis of specific skin diseases
17/01/2018 Cardiovascular and cerebrovascular safety of testosterone replacement therapy in hypogonadal men
18/12/2017 Dementia and Musculoskeletal Pain: Consultation and Treatment Patterns in Primary Care
18/12/2017 Methodological guidelines for the use of regression discontinuity designs in clinical settings.
18/12/2017 Use of metformin add on to insulin among patients diagnosed Type 1 diabetes mellitus in UK
18/12/2017 Assessing the Burden of Illness of Generalised Refractory Myasthenia Gravis in England, using the CPRD database
08/12/2017 Risk of nephrotic syndrome among non-steroidal anti-inflammatory drug users: a population-based study in the United Kingdom
27/11/2017 Prescribing patterns of glucosamine containing products- a study using CPRD
27/11/2017 Healthcare Resource Utilization and Costs among Patients with and without Infection after Intramedullary Nailing for A Tibial Shaft Fracture
24/11/2017 Treatment Patterns and Characteristics of Patients with Uterine Fibroids in the UK: A Retrospective Cohort Study
24/11/2017 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 1 - Replication of "Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study"
22/11/2017 Outcomes following empirical antibiotic treatment of suspected urinary tract infection in older people in primary care.
21/11/2017 An exploratory study on the consistency and temporal variation of renal function of T2DM patients over time.
17/11/2017 Exploratory study of cardiovascular risk in early type 2 diabetes