Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
13/03/2020 Analysing the effect of lithium cessation on renal function in patients with bipolar disorder
11/03/2020 Risk of death in childhood epilepsy
04/03/2020 Measuring the incidence and prevalence of menstrual disorders in the UK Clinical Practice Research Datalink
04/03/2020 Risk factors for pertussis in older adults aged 50 years and above, and the incidence and economic burden of pertussis overall and in high-risk groups using the merged CPRD GOLD and Aurum database, and Hospital Episode Statistics (HES)
28/02/2020 SELECT: Selection of Eligible People for Lung Cancer Screening using Electronic Primary Care DaTa: Validation of pre-existing prediction models
28/02/2020 Utilisation, effectiveness, and safety of direct oral anticoagulants in patients with non-valvular atrial fibrillation and liver disease
27/02/2020 Screening for diabetes and glucose intolerance disorders after gestational diabetes in primary care: A retrospective cohort analysis from the UK Clinical Practice Research Datalink (CPRD)
27/02/2020 Association of diabetes control on the risk of venous thrombosis: a nested case control study
18/02/2020 A retrospective cohort study to assess whether urate lowering therapy improves outcomes in patients with hyperuricemia and/or gout with a history of heart failure
13/02/2020 Determinants of treatment patterns of Parkinson's Disease in the United Kingdom
10/02/2020 Time Trends in identification of Autism Spectrum Disorders
10/02/2020 Incidence, prevalence, treatment patterns and health care resource use of women with vasomotor symptoms in the UK: A descriptive study using electronic medical records
07/02/2020 Cardiovascular comorbidity prevalence in males with haemophilia A
31/01/2020 Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with peripheral artery disease (PAD) and with PAD related lower-extremity revascularization (PAD-LER)
31/01/2020 Real World Effectiveness and Adverse Events Caused by ACE inhibitors and ARBs for Reduction in Cardiovascular Events
27/01/2020 Prevalence, Treatment Pathway and Patient Outcomes of Primary Hypercholesterolaemia and Dyslipidaemia in England: The 4Ps Study
23/01/2020 Use of Hydrochlorothiazide and the Risk of Melanoma and Non-Melanoma Skin Cancer: A Population-Based Cohort Study
17/01/2020 Examining neurologic and thromboembolic risks when using skeletal muscle relaxants with warfarin
17/01/2020 Mapping the risk of post-diagnosis infections in patients with multiple sclerosis in the UK population
16/01/2020 An observational study of comorbidities and clinical events among patients with Progressive Supranuclear Palsy (PSP)