Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
24/01/2019 C-reactive protein as a biomarker of response to inhaled corticosteroids in COPD
22/01/2019 Life-Limiting Conditions: the health of children and their Mothers
17/01/2019 Dose adjustment or discontinuous use of direct oral anticoagulants related to the concurrent use of potential interacting drugs
17/01/2019 Identifying predictors of drug treatment response in bipolar disorder
17/01/2019 Effectiveness of long acting muscarinic-antagonist- (LAMA) as an add-on to inhaled corticosteroids / long acting beta-agonists (LABA) in smoking asthmatics
10/01/2019 Understanding the Relationship between Multimorbidity in Later Life, Use of Health Services and Costs of Health Care (MuSeCol)
10/01/2019 Guideline discordant diagnostic care: when do primary care referrals not reflect guidelines for suspected cancer?
10/01/2019 Mapping the opportunities for earlier diagnosis and characterising the management costs of psoriasis and impact of key co-morbidities
02/01/2019 An epidemiological study to compare adverse events associated with different formulations of latanoprost
21/12/2018 The pattern of incident fractures in patients with diabetes mellitus compared to matched controls
19/12/2018 The Health Economic Burden of Atopic Dermatitis and Associated Dermatologic Conditions: A Study of Cow's Milk Allergy (CMA) in patients > 5 years of age in the Primary and Secondary Care Pathways
19/12/2018 Testing a data-based definition of severity in atopic dermatitis in a linked primary and secondary care dataset in England: Implications on clinical outcomes and healthcare resource use
14/12/2018 Translation of the electronic Frailty Index for use with the International Statistical Classification of Diseases and Related Health Problems tool in hip and knee replacement patients
11/12/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 3 -Replication of "Non-persistence and non-adherence of patients with Type 2 Diabetes Mellitus in Therapy with GLP-1 Receptor Agonists: A Retrospective Analysis"
11/12/2018 Identifying population groups at risk of avoidable hospitalisations for community acquired pneumonia in the UK.
11/12/2018 Evaluating the risk of macrovascular events, disability, and mortality in individuals with multiple sclerosis in England: a population-based retrospective cohort study
11/12/2018 All-cause and cardio-renal-metabolic mortality in people with or without type 2 diabetes: a comparative international trend study
11/12/2018 The Costs and Complications of Colostomy, Ileostomy and Urostomy in England in Primary and Secondary Care: A 10-Year Study using Real World Datasets
05/12/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 20 - Replication of "Risk of Death and Cardiovascular Outcomes with Thiazolidinediones: A Study with the General Practice Research Database and Secondary Care Data"
30/11/2018 REPEAT Study 17 - Replication of "Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study"