Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
02/05/2018 Describing the Cumulative Anticholinergic Burden in Patients Over the Age of 65, With Overactive Bladder, and the Association to Healthcare Resource Utilization. A Retrospective Observational Study Using UK Electronic Medical Records (EMR) data.
30/04/2018 Health care use and cost trajectories of people in the last year of life : improving planning and resource allocation in end of life care
30/04/2018 The epidemiology and healthcare burden of opioid therapy in the United Kingdom
30/04/2018 The impact of type 2 diabetes on survival in patients with cancer independent of its effect on survival in individuals without cancer: a matched cohort analysis
26/04/2018 5-ASA in Crohn's Disease: The CROHN'S Investigation (Clinical and treatment Resource use, patient Outcomes and Health impact using National prescribing Systems)
26/04/2018 Blood Eosinophil Levels and Severe Asthma Exacerbations Among Paediatric Patients with Asthma in the English Primary Care Setting
25/04/2018 Mapping opportunities for earlier detection of Bipolar Disorder - Linking big data to improve patient outcomes (MOBILISE)
25/04/2018 Unmet Needs, Symptom Burden, and Health Care Utilisation of Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Respiratory Maintenance Therapy in the United Kingdom (UK)
20/04/2018 Identifying and Evaluating Modifiers of Subsequent Event Risk among Patients with Established Coronary Heart Disease
20/04/2018 Management of hyperthyroidism in pregnancy; data from a large UK primary care cohort
18/04/2018 Pharmaco-Epidemiological Study of Cardio-Respiratory Safety of Beta2-agonists for the Treatment and Management of Asthma-COPD Overlap Syndrome
18/04/2018 Cessation of renin-angiotensin system inhibitors after acute kidney injury and outcome
18/04/2018 Antibiotic Choice in UK General Practice - rates and drivers of potentially inappropriate antibiotic type in UK general practices
18/04/2018 A retrospective observational study describing the health impact of SABA over-prescription and ICS under-prescription among asthma patients
11/04/2018 Utilisation of Ulipristal acetate 5mg, long-term treatment patterns, resource utilisation in a population-based cohort in UK using the THIN and CPRD databases
06/04/2018 Weight change and the onset and progression of cardiovascular diseases in large scale electronic health records
05/04/2018 Abdominal pain in primary care: establishing a clinical profile and diagnostic pathway for identifying cancer
05/04/2018 Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with coronary artery disease (CAD), peripheral artery disease (PAD), and CAD or PAD
05/04/2018 Comparison of Outcomes for Patients Hospitalised for Heart Failure (HHF) in the UK, Japan, USA and Taiwan
03/04/2018 Individual-level cost-of-illness Analysis for FoResight and Modelling for European HEalth Policy and Regulation (FRESHER) Project using linked English Data