Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
05/01/2016 Mapping patient cohort data from a clinical coding space into a distance space: novel tools for hypothesis generation, stratification and cohort identification.
04/01/2016 Domperidone and risk of primary liver cancer in the UK Clinical Practice Research Datalink
31/12/2015 Association between Diabetes Mellitus and Incident Meniere's Disease
23/12/2015 Novel Prediction Models for the One-Year Competing Risks of Death, Stroke, Intracranial Hemorrhage, and Extracranial Hemorrhage in Adults with Incident Non-Valvular Atrial Fibrillation
22/12/2015 Psychological stress and risk of herpes zoster
21/12/2015 Comparison of the risk of acute outcomes between patients with type 2 diabetes exposed to dapagliflozin and those exposed to other antidiabetic treatments
18/12/2015 Descriptive study of patients with haemophilia in the CPRD.
14/12/2015 Trends and factors associated with therapy decisions in newly diagnosed COPD patients in GOLD groups A and B. A non-interventional study using the Clinical Practice Research Datalink (CPRD) database
08/12/2015 Patterns of prescribing in end of life care using CPRD data.
08/12/2015 Congenital malformations and maternal use of anti-hypertensive medication in the UK
03/12/2015 Clinical & Economic Burden of Diabetic Foot Ulcer Care Pathways in the UK
02/12/2015 Descriptive study of patients in the CPRD with lysosomal function disorders.
02/12/2015 Use of Finasteride 1mg for Alopecia and the Incidence of Erectile Dysfunction (ED)
30/11/2015 Association between Use of Beta-blockers or Diuretics and Incident Meniere's Disease
30/11/2015 A descriptive study of LAIV utilization to identify and characterize medication errors due to expired vaccine use in individuals 2-17 years of age in the CPRD
27/11/2015 Prescribing Trends of ADHD Medications in UK Primary Care
26/11/2015 Comparison of the performance of the English NHS Health Checks & Scottish Keep Well programmes
19/11/2015 Effects of selective serotonin reuptake inhibitors on the risk of mortality in patients with epilepsy: a CALIBER study using linked data
19/11/2015 Using pharmacoepidemiology to test medications associated with altered breast cancer risk identified from connectivity mapping
17/11/2015 The role of systemic inflammatory diseases in long-term morbidity and mortality: a retrospective, matched-cohort study in the Clinical Practice Research Datalink