Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
18/10/2016 Use of novel regression discontinuity design to investigate safety of statins in the UK Clinical Practice Research Datalink
14/10/2016 What are the long-term health outcomes in low birth weight and premature babies born with chronic lung disease who are discharged home on oxygen?
13/10/2016 Oophorectomy and risk of primary liver cancer and fatty liver disease among women in the UK Clinical Practice Research Datalink
13/10/2016 Rates of cytomegalovirus among children with organ transplants
13/10/2016 Renal Outcomes with DPP-4 Inhibitors Compared with Sulfonylurea as Add-on to Metformin among Patients with Type 2 Diabetes Mellitus in the UK
13/10/2016 Aclidinium Bromide Post-Authorisation Safety Study to Evaluate the Risk of Cardiovascular Endpoints: Mortality Study
11/10/2016 The relationship between prior antibiotic exposure and antibiotic "response failure" in children presenting with acute respiratory tract infections (RTI) in primary care: an observational cohort study
30/09/2016 Estimating the annual incidence of paediatric burns across the United Kingdom
22/09/2016 Metformin and the incidence of viral-induced cancers in patients with Type-2 diabetes
14/09/2016 Trends in the prescription of oral anticoagulants in UK primary care (2009-2015)
24/08/2016 The role of social determinants in vaccine uptake and burden of vaccine preventable diseases
24/08/2016 Body mass index and cause-specific mortality - population-based cohort study using record linkage
23/08/2016 Hormone Therapy in Relation to Risks of Second Cancers and Mortality Among Women and Men
23/08/2016 Domperidone for insufficient lactation: a drug utilization study with interrupted time-series analysis
22/08/2016 A feasibility study to develop within primary care IT systems a computer program for flagging patients with risk factors for HIV who would benefit from having an HIV test
22/08/2016 Weight loss as a predictor of cancer and serious disease in primary care.
17/08/2016 Residual Risk and Burden of Cardiovascular Diseases in the United Kingdom
16/08/2016 External validation of risk scores for dementia in the CPRD population
15/08/2016 Comprehensive ascertainment of bleeding in patients prescribed different combinations of dual antiplatelet therapy (DAPT) and triple therapy (TT, DAPT plus an anticoagulant) after coronary interventions in the UK (The ADAPTT Study).
02/08/2016 Metabolic syndrome and risk of meningioma - population-based case-control analysis