Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

 

ISAC Approval Date Title
02/08/2016 Obstructive airway disease phenotype discovery using cluster analysis techniques in CPRD
02/08/2016 Comparison of information on diagnosis of musculoskeletal outcomes in the Million Women Study cohort and CPRD-GOLD: a record linkage study
01/08/2016 Use and costs of primary care consultations and prescription medications in relation to body mass index in middle-aged UK women
01/08/2016 Comparison of Health Economic Outcomes for Patients with Asthma who switch from Seretide to flutiform or Fostair using the CPRD-HES Linked Database
29/07/2016 Trimethoprim and sudden death in patients over 65 years with urinary tract infection
28/07/2016 An analytical framework for increasing the efficiency and validity of research using primary care databases
28/07/2016 Safety and associated costs of glucocorticoid therapy for the treatment of chronic inflammatory diseases
28/07/2016 Association between cardiovascular disease and zoster risk - case-control study in the Clinical Practice Research Datalink
25/07/2016 Proton pump inhibitor use and risk of developing Alzheimer's disease or vascular dementia
20/07/2016 Risk of major bleeds associated with the use of direct oral anticoagulants in venous thromboembolism
20/07/2016 Characteristics of patients initiating empagliflozin or other non-insulin glucose lowering drugs in the United Kingdom
20/07/2016 Use of Nalmefene (Selincro) in the UK: Cohort design using longitudinal electronic medical records (EMR)
20/07/2016 Longitudinal Analyses of Body Mass Index and Risk of Parkinson's Disease in CPRD
20/07/2016 Estimation of undiagnosed lysosomal acid lipase deficiency in a paediatric population: a UK database study
19/07/2016 Unsupervised clustering and topological analysis of Type-2 Diabetes and prediabetes patients in CALIBER using clinical data from electronic medical records
12/07/2016 Linaclotide Utilisation Study in the UK - Extended Feasibility Counts
11/07/2016 Cancer and risk of herpes zoster - case-control study in the Clinical Practice Research Datalink
11/07/2016 Age- and lifestyle-related chronic disease and causes of mortality among adults with cerebral palsy in the United Kingdom.
07/07/2016 Profiling the natural history of Crigler-Najjar syndrome using the Clinical Practice Research Datalink
06/07/2016 Sequelae of gastrointestinal infections: incidence, risk factors, and economic impact on primary and secondary care settings.