Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
19/10/2015 Usage Patterns of Selected Systemic NSAIDs (Including Diclofenac): A Retrospective Cohort Study
14/10/2015 The association between lansoprazole and tuberculosis disease; a primary care based cohort study
14/10/2015 A study of multifactorial intervention in type 2 diabetes and chronic kidney disease
12/10/2015 The efficacy and safety of concomitant treatment with telmisartan, candesartan or bisoprolol in combination with amlodipine in patients with essential arterial hypertension: outcomes in real world practice
08/10/2015 The risk of depression and suicidality in patients with psoriasis, psoriatic arthritis or ankylosing spondylitis: a retrospective United Kingdom database analysis
06/10/2015 Effects of pulmonary rehabilitation on exacerbation number and severity in people with Chronic Obstructive Pulmonary Disease
06/10/2015 The association between Huntington's disease and cancer before and after the Huntington's diagnosis - a two-phase study
05/10/2015 An evaluation of the epidemiology and burden of illness of congenital adrenal hyperplasia in the United Kingdom
02/10/2015 Evaluation of the clinical and economic outcomes associated with Bydureon versus basal insulin in people with type 2 diabetes
23/09/2015 Evidence for and implications of channeling in the use of nonprescription acetaminophen and ibuprofen in an electronic medical records database
22/09/2015 The risk of fragility fracture in inflammatory arthritis: evidence for the effective and equitable targeting of prevention
18/09/2015 Study to investigate the drug treatment for sialorrhoea in children over the past 10 years.
15/09/2015 Can Continuity Of Primary Care Decrease Unscheduled Secondary Care Use?
15/09/2015 Assessing channelling bias and effectiveness in newly marketed glucose-lowering medications - a retrospective cohort study
14/09/2015 The incidence of Guillain-Barre Syndrome in the United Kingdom from April 2005 to March 2015.
11/09/2015 Healthcare resource utilisation and economic impact among kidney transplant patients during the last year before graft failure in the UK: a retrospective observational study
11/09/2015 Healthcare resource utilisation and economic impact among liver transplant patients during the last year before graft failure in the UK: a retrospective observational study
04/09/2015 Time to treatment intensification and associated outcomes among patients with Type 2 diabetes mellitus in the UK
01/09/2015 Medical resource use and costs associated with diabetes complications in the population of diabetes patients receiving insulin therapy in the United Kingdom
28/08/2015 Demographic and clinical characteristics of T2DM patients treated with DPP-4 and SGLT2 inhibitors in the absence of a current clinical guideline - A CPRD Study