Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
08/01/2020 Comparison of the prevalent new user and active comparator new user designs for assessing the real-world safety and effectiveness of medications
08/01/2020 GARFIELD-AF in Primary care - Optimising prediction of mortality, stroke and major bleeding for patients with atrial fibrillation using routinely collected primary care electronic health records
06/01/2020 Use of electronic primary care records to obtain control populations for assessing excess risk of long-term morbidity and mortality in chronic diseases
06/01/2020 Sodium-glucose transport protein 2 inhibitors and the risk of early breast cancer
03/01/2020 Heart failure burden of illness and characterisation of patients by treatments, comorbidities and ejection fraction - an observational study
20/12/2019 Developing risk prediction models to support individualised HbA1c target setting using routinely collected primary and secondary care data from the United Kingdom (UK)
20/12/2019 Comparative effectiveness and safety of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on the risk of major cardiovascular events, cancer and renal outcomes
20/12/2019 Risk of skin cancer associated with use of thiazides and thiazide-like diuretics: a cohort study
18/12/2019 Cardiovascular Risk Profiles: Comparing the Glucagon-Like Peptide-1 Receptor Agonist Cardiovascular Outcomes Trials REWIND, LEADER and SUSTAIN-6 in a Real World Population with Type 2 Diabetes in UK Primary Care
17/12/2019 External validation study investigating the association between hormonal contraceptives and asthma onset in females of reproductive age
17/12/2019 Improved characterization of the overlap syndrome of heart failure, diabetes mellitus and chronic kidney disease
13/12/2019 Assessment of production batch information of vaccines in the Clinical Practice Research Datalink
06/12/2019 The prevalence of liver enzyme and function testing in UK primary care
28/11/2019 Infectious burden and the risk of incident dementia: a nested case-control study
27/11/2019 Spillover effects of removing indicators from the Quality and Outcomes Framework
27/11/2019 The economic and clinical burden of hyperkalaemia in England: a retrospective cohort study using the Clinical Practice Research Datalink
27/11/2019 Identifying and describing the burden of morbidity following major surgery: a linked electronic health records cohort study
21/11/2019 Safety of colchicine prophylaxis when initiating urate-lowering therapy for gout and prognostic factors for adverse events: an observational study in UK primary care using the Clinical Practice Research Datalink
20/11/2019 Co-prescribing of aldosterone antagonist and renin-angiotensin system drugs for heart failure in the UK primary care: assessing the impact of regulatory action
20/11/2019 Comparative effectiveness of the cardiorenal disease outcomes between SGLT-2i and DPP-4i medication in population with type 2 diabetes - an observational study across England