Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
17/11/2017 Metabolic effects in children and adolescents treated with psychotropic medication in primary care
03/11/2017 Estimation of the proportion of paediatric, adolescent and adult asthma patients according to modified GINA guidelines
30/10/2017 A UK population-based cohort study of risk factors for premature death in epilepsy
30/10/2017 Degree of serotonin reuptake inhibition of antidepressants and the risk of ischaemic stroke and myocardial infarction: a nested case control study
27/10/2017 The association between continuity of primary care and mortality and emergency hospitalisation for older patients with complex multimorbidity
23/10/2017 The impact of polypharmacy on health outcomes in older patients: a retrospective cohort study using CPRD database.
18/10/2017 The health care use and cost of care before and after the diagnosis of six selected endocrine diseases in UK patients
17/10/2017 Real-world comparison of Qvar® BAI versus Qvar® MDI and all beclometasone MDI for the treatment of asthma based on a UK retrospective database study
12/10/2017 Primary care prescriptions of nephrotoxic medications in children with a previous episode of acute kidney injury or with a diagnosis of chronic kidney disease
11/10/2017 The adverse effects of tramadol
09/10/2017 Healthcare resource utilization among patients diagnosed with Systemic Sclerosis-associated Interstitial Lung Disease in the United Kingdom: An observational study using the Clinical Practice Research Datalink - INTERSTELLAR
06/10/2017 Treatment of venous thromboembolism in England: an observational cohort study using Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics databases
06/10/2017 AChEIs and the Risk of Acute Ischemic Events and Bleeding in Patients with AD
05/10/2017 Derivation and validation of a clinical algorithm to predict patient cholesterol response to the initiation of statins and cardiovascular outcomes.
29/09/2017 Association between the prevalence of cardiovascular risk factors and new use of testosterone
29/09/2017 Cardiovascular Outcomes and Mortality in Cardio-Renal-Metabolic Disease Progression in Type 2 Diabetes Mellitus Patients within the United Kingdom
19/09/2017 the safety and effectiveness of direct oral anticoagulants antagonists in conditions that elevate drug concentrations
18/09/2017 National patterns in anti-asthmatic treatment in general practice: a descriptive study using data from the Clinical Practice Research Datalink.
13/09/2017 Treatment with DPP-4 inhibitors, adherence to Summary of Product Characteristics and therapy adjustment.
13/09/2017 Quantifying the severity of chronic conditions in English Primary Care using the Clinical Practice Research Datalink