Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
11/06/2018 Investigating the potential side effects of the human papillomavirus vaccine: a novel regression discontinuity analysis using the UK Clinical Practice Research Datalink
11/06/2018 Deriving parameters of long-term cardiovascular outcomes and health care utilisation for a cost-effectiveness model in patients with familial hypercholesterolaemia diagnosed in primary care
11/06/2018 Use of primary care and hospital services in children aged less than 15 years in England; descriptive study
08/06/2018 The utilisation of linaclotide in patients with Irritable Bowel Syndrome predominantly with constipation (IBS-C) in the United Kingdom: a retrospective observational study using the Clinical Practice Research Datalink
08/06/2018 The cumulative incidence of seizures during 21 days after new use of oral antibiotics - a cohort study
08/06/2018 Prescribing of high dose oral ibuprofen (1800mg/day or more) in UK primary care
08/06/2018 Replication of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) in a cohort study using electronic primary care data
01/06/2018 Determinants associated with treatment modification in the first year of treatment in patients with type 2 diabetes mellitus in the United Kingdom, before and after implementation of the new guideline: a retrospective cohort study
01/06/2018 Rate and risk of cardiovascular events and all-cause mortality in individuals with type 2 diabetes, with and without microalbuminuria - a cohort study in the CPRD database
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 6 - Replication of "Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK CPRD"
30/05/2018 Persistence and adherence to controlled release formulations of sodium valproate for the treatment of epilepsy and their clinical and resource use implications.
30/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 11 - Replication of "Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population"
25/05/2018 Up-titration and distribution of dose of metformin monotherapy in the real-world
23/05/2018 Acute exacerbation of idiopathic pulmonary fibrosis in the UK: incidence, mortality and disease severity
23/05/2018 Use of non-steroidal anti-inflammatory drugs and risk of acute myocardial infarction in patients undergone total hip or knee replacement surgery: a population-based cohort study
22/05/2018 Evaluation of the Burden and Management of Musculoskeletal Diseases
22/05/2018 The Association of oral bisphosphonate use with mortality risk following a major osteoporotic fracture in the UK
21/05/2018 Blood eosinophilia, withdrawal of inhaled corticosteroids and risk of COPD exacerbations and mortality
21/05/2018 Trends in acute exacerbation and related hospitalization among COPD patients in the UK (2005-2013)
21/05/2018 Treatment patterns and burden of agitation in patients with Alzheimer's disease in the UK