Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
08/10/2019 The Plan-it study: The acceptability and feasibility of a planned pre-pregnancy weight loss intervention
08/10/2019 Post Authorisation Safety Study (PASS) to Evaluate the Risks of Hepatotoxicity and Nephrotoxicity from Administration of Methoxyflurane (Penthrox) for Pain Relief in Hospital Accident & Emergency Departments in the United Kingdom
07/10/2019 Impact of variability in patient characteristics on effect estimates in observational studies: a retrospective multi-cohort study of rivaroxaban versus warfarin
03/10/2019 Polypharmacy and the impact of drug interactions with direct oral anticoagulants (DOACs)
27/09/2019 Patient pathway and therapeutic inertia in newly diagnosed T2DM patients with multimorbidity
26/09/2019 Treatment, Complications, and Costs in Clavicle Fracture and Acromioclavicular Dislocation
19/09/2019 Burden of pneumococcal disease and pneumococcal vaccination in adults with underlying medical conditions in the UK
19/09/2019 Ageing Inequalities: A cohort study to investigate delay in diagnosis and inequalities in treatment of dementia and cancer in the elderly
19/09/2019 Effectiveness of BISOprolol on high blood PRESSure versus other Beta -blockers, and versus other anti-hypertensive classes. A cohort study in the UK Clinical Practice Research Datalink (CPRD)
11/09/2019 Hypertensive disorders of pregnancy and risk of cardiovascular disease in women: electronic cohort study in primary care
06/09/2019 Utilization of routinely performed diagnostic tests in primary care
05/09/2019 Evaluation of the survival, treatment pathways and liver disease outcomes of patients with liver disease and their progression to cirrhosis and hepatic encephalopathy: a non-interventional study using primary and secondary healthcare data from the UK
30/08/2019 GLP-1 receptor agonists and the risk of anaphylactic reactions among patients with type 2 diabetes
28/08/2019 A real-world study comparing the effectiveness and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose co-transporter 2 inhibitors (SGLT-2is) in patients with type 2 diabetes
22/08/2019 Comparative Long-Term Effectiveness of Treatments for Patients with Drug-Resistant Epilepsy: a descriptive study
20/08/2019 A multi-database retrospective study of the comparative efficacy and safety of SGLT2 inhibitors in the management of type 2 diabetes (EMPRISE-UK)
20/08/2019 Estimating primary and secondary healthcare resource costs for people with type 1 and type 2 diabetes in the United Kingdom
12/08/2019 Statins and the risk of Venous Thromboembolism
07/08/2019 The long-term impact of vaginal surgical mesh devices in UK primary care: a cohort study in the CPRD
05/08/2019 Association of Polycystic Ovary Syndrome with patient and offspring cardiometabolic outcomes: a retrospective, observational study