Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
10/07/2018 The combine effect of renin angiotensin aldosterone system blockage and Sodium-glucose co-transporter-2 receptor inhibition on renal outcomes in type 2 diabetes
10/07/2018 The extent of medication complexity in general practice
09/07/2018 Impact of ethnicity on the development of kidney disease in the UK, a retrospective database study
09/07/2018 Risk Stratification and multimorbidity in Chronic Obstructive Pulmonary Disease (COPD)
04/07/2018 Prognostic relevance of severe hypoglycaemia and factors associated with poor outcomes in subjects experiencing severe hypoglycaemia
04/07/2018 A cohort study investigating the association of flucloxacillin and liver injury within people previously exposed to the drug
28/06/2018 Is herpes zoster associated with risk of incident dementia? A cohort study using the Clinical Practice Research Datalink.
28/06/2018 Risk factors for overtreatment and undertreatment of glucose-control in patients with diabetes mellitus and association of overtreatment with mortality
22/06/2018 Prevalence, incidence, and natural history of gastroparesis in the United Kingdom: real world evidence from the Clinical Practice Research Datalink
20/06/2018 Health Impact Assessment to predict the impact of an increase in tobacco pricing on the burden of COPD in Italy, Sweden and the United Kingdom
20/06/2018 The impact of not speaking English as a first language on diabetes control and outcomes in primary care
18/06/2018 Investigating healthcare utilisation for heart failure patients with or without cardiac implantable electronic devices in England: retrospective cohort study.
15/06/2018 What influence does obesity have on healthcare utilisation cost for patients with and without cardiovascular diseases?
15/06/2018 Comparing the effectiveness of COPD treatments in the UK
14/06/2018 Descriptive Analysis of Pro-Arrhythmic Risk of Drug Therapies
11/06/2018 Investigating the potential side effects of the human papillomavirus vaccine: a novel regression discontinuity analysis using the UK Clinical Practice Research Datalink
11/06/2018 Deriving parameters of long-term cardiovascular outcomes and health care utilisation for a cost-effectiveness model in patients with familial hypercholesterolaemia diagnosed in primary care
11/06/2018 Use of primary care and hospital services in children aged less than 15 years in England; descriptive study
08/06/2018 The utilisation of linaclotide in patients with Irritable Bowel Syndrome predominantly with constipation (IBS-C) in the United Kingdom: a retrospective observational study using the Clinical Practice Research Datalink
08/06/2018 The cumulative incidence of seizures during 21 days after new use of oral antibiotics - a cohort study