Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
11/04/2016 Vaccine effectiveness of the national rotavirus vaccination programme against acute gastroenteritis in England
12/04/2016 An epidemiological study of diabetes and diabetes-related morbidities in the UK children and young adults
19/04/2016 Historical cohort study to evaluate undertreatment and disease outcomes for patients with coexisting Heart Failure and Chronic Obstructive Pulmonary Disease
20/04/2016 Characterization of patients with COPD by mepolizumab eligibility criteria
20/04/2016 Association Between Blood Eosinophil Level and Exacerbation Risk in Patients with COPD
20/04/2016 Developing and validating a risk prediction model based on frailty syndrome using primary care data
20/04/2016 The epidemiology and treatment patterns of patients with Gastro-oesophageal reflux disease (GORD) in routine general practice.
21/04/2016 Assessing drivers of effectiveness and safety using real life data: anticoagulants as a case study
21/04/2016 Urinary tract infections in the elderly - care pathways and characteristics
21/04/2016 A Retrospective Descriptive Study of the Cohort of Type 2 Diabetes Mellitus Patients Initiating a Second-line Therapy in the United Kingdom Clinical Practice Research Datalink (CPRD) Database
21/04/2016 A prevalence and incidence study of multimorbidity in the UK using the Clinical Practice Research Datalink (CPRD)
21/04/2016 Determinants of exacerbations of asthma
29/04/2016 Premature mortality and non-fatal self-harm in patients diagnosed with Chronic Fatigue Syndrome
03/05/2016 Descriptive Epidemiology of Multimorbidity in Primary Care: A Cross-Sectional Study
03/05/2016 Treatment choice and outcomes associated with dry powder inhaler and Tiotropium Respimat monotherapy in COPD (chronic obstructive pulmonary disease) patients
12/05/2016 Does the use of inhaled corticosteroids increase the incidence and disease burden of Type 2 Diabetes, osteoporosis or pneumonia compared to non-ICS therapies in patients with Chronic Obstructive Pulmonary Disease.
17/05/2016 Estimation of multi-treatment effects from observational data with application to diabetes mellitus
17/05/2016 Burden of medically attended acute gastroenteritis and aetiology: a cohort study in CPRD in England.
17/05/2016 A longitudinal safety study of patients with psoriasis and psoriatic arthritis treated with either Otezla (apremilast) or a comparator drug
18/05/2016 Development of an identification tool for patients over 65 years at risk of death or emergency hospital admission during cold weather.