Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
04/09/2015 Time to treatment intensification and associated outcomes among patients with Type 2 diabetes mellitus in the UK
01/09/2015 Medical resource use and costs associated with diabetes complications in the population of diabetes patients receiving insulin therapy in the United Kingdom
28/08/2015 Demographic and clinical characteristics of T2DM patients treated with DPP-4 and SGLT2 inhibitors in the absence of a current clinical guideline - A CPRD Study
28/08/2015 Characteristics of newly diagnosed adults with Type 1 diabetes in the UK and their evolution over the first 5 years
28/08/2015 Cluster Headache Patient Prevalence and Prescribed Treatments in the UK Clinical Practice Research Datalink
18/08/2015 Risk of fragility fracture across inflammatory conditions: a UK population study
17/08/2015 Alcohol misuse and injury outcomes in adolescents aged 10-24 using linked UK health data
12/08/2015 Mortality of people with learning disability
07/08/2015 A drug utilisation cohort study of patients prescribed medicines from different classes of renin-angiotensin system blocking agents in UK primary care
05/08/2015 Use of COX-2 inhibitors and risk of glioma
31/07/2015 Characterising the natural history and risk factors for the development of psoriatic arthritis in a UK population
23/07/2015 The effect of metformin on patient outcome after acute myocardial infarction
17/07/2015 To establish the causal roles of environmental factors on exacerbations of COPD
15/07/2015 The impact of obesity on healthcare resource utilisation.