Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
20/11/2019 Comparative effectiveness of the cardiorenal disease outcomes between SGLT-2i and DPP-4i medication in population with type 2 diabetes - an observational study across England
15/11/2019 Utilization and comparative effectiveness and safety of long-acting insulins and Neutral Protamine Hagedorn (NPH) in patients with type 2 diabetes
11/11/2019 Incidence of adverse events among adult users of insulin and apomorphine pumps in the United Kingdom Clinical Practice Research Datalink GOLD: a descriptive study
08/11/2019 The association between anticoagulants and cancer incidence among individuals with atrial fibrillation.
08/11/2019 Eosinophilic asthma phenotypes and associated clinical outcomes
06/11/2019 DISCOVER CKD: An observational study incorporating UK CPRD data to evaluate and describe the journey and management of patients with chronic kidney disease (CKD).
01/11/2019 Which histological subtypes of lung cancer exhibit underlying pre-diagnostic thrombocytosis?
01/11/2019 Patient and clinical characteristics of new users to single or multiple inhaled triple therapy in patients with COPD in the UK
01/11/2019 Comparative effectiveness and safety of NOACs versus warfarin in UK patients with non-valvular atrial fibrillation and type 2 diabetes: a retrospective cohort study
30/10/2019 Association of chronic kidney disease with frailty and mortality in the multi-ethnic UK population: a CPRD study
25/10/2019 Health care demand modelling - Time series analysis of the incidence and prevalence of multiple chronic conditions and comorbidities in England from primary care data
24/10/2019 Burden of hip dislocation following total hip arthroplasty in England.
16/10/2019 Use of sodium-glucose co-transporter-2 inhibitors (SGLT-2-Is) and risk of lower limb amputation.
11/10/2019 The effect of low-dose oral glucocorticoid therapy on osteoporotic fracture risk in patients with rheumatoid arthritis: the UK Clinical Practice Research Datalink GOLD
11/10/2019 Effect of raised cardiovascular risk on the rates of acute respiratory infections and subsequent cardiovascular complications: a cohort study using electronic health records
09/10/2019 Cardiovascular prognosis in patients with undiagnosed chest pain: an electronic health record cohort study
09/10/2019 Characterization of the deterioration of type 2 diabetes in patients with a subsequent diagnosis of pancreatic cancer - A descriptive study
09/10/2019 Cohort study examining mortality and physical morbidity outcomes among patients diagnosed with an eating disorder
08/10/2019 The Plan-it study: The acceptability and feasibility of a planned pre-pregnancy weight loss intervention
08/10/2019 Post Authorisation Safety Study (PASS) to Evaluate the Risks of Hepatotoxicity and Nephrotoxicity from Administration of Methoxyflurane (Penthrox) for Pain Relief in Hospital Accident & Emergency Departments in the United Kingdom