Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
03/08/2017 Identification of high cost patients in primary and secondary care and an analysis of their utilisation patterns, and social and demographic characteristics.
03/08/2017 Alzheimer's treatment and the risk of serious adverse events
03/08/2017 Cardiovascular risk prediction in daily practice: are risk scores such as QRISK2 accurate enough to be used for individual patient care?
01/08/2017 Clinical profile of pre-defined asthma phenotypes in a large cohort of UK primary care patients (CPRD).
26/07/2017 The routine use of electronic healthcare record data to strengthen signal evaluation and early pharmacovigilance decision making in UK medicines regulation
26/07/2017 Treatment of acute lower respiratory tract infections in patients with and without asthma
25/07/2017 Investigating the impact of the introduction of a named GP assigned to patients 75 and over on their continuity of care and emergency hospital admission
25/07/2017 Seizure frequency and resource utilisation associated with initiation of perampanel, eslicarbazepine and rufinamide in patients with epilepsy
25/07/2017 Healthcare resource utilisation and costs of major bleeding events and ischemic stroke among non-valvular atrial fibrillations patients in the UK
25/07/2017 Effects of financially-induced inhaler switching on the risk of an acute exacerbation in patients with asthma or chronic obstructive pulmonary disease (COPD): a self-controlled case series
25/07/2017 Characterising the risk of major bleeding in patients with Non-Valvular Atrial Fibrillation: non-interventional study of patients taking Direct Oral Anticoagulants in the EU
24/07/2017 Eligibility for blood pressure lowering treatment and subsequent cardiovascular disease burden under four different treatment approaches: a cohort study
20/07/2017 Impact of the definition of osteoarthritis and the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink.
18/07/2017 Can CHA2DS2-VASc score be used to identify patients under 65 years old at high risk of atrial fibrillation?
18/07/2017 Incidence of major bleeding events and ischaemic stroke among non-valvular atrial fibrillation patients in the UK
18/07/2017 The association between glycated haemoglobin (HbA1c), glycaemia and chronic kidney disease with or without anaemia.
18/07/2017 Steroid Use and the risk of Venous Thromboembolism in Asthma Patients
14/07/2017 Quantifying variation in UK primary care test use: A 15 year retrospective CPRD analysis of temporal and geographical variation in test use.
14/07/2017 Impact of methods for measuring the prevalence and incidence of chronic disease in the UK population based on electronic medical record (EMR) data