Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
17/01/2018 Cardiovascular and cerebrovascular safety of testosterone replacement therapy in hypogonadal men
18/12/2017 Methodological guidelines for the use of regression discontinuity designs in clinical settings.
18/12/2017 Dementia and Musculoskeletal Pain: Consultation and Treatment Patterns in Primary Care
18/12/2017 Use of metformin add on to insulin among patients diagnosed Type 1 diabetes mellitus in UK
18/12/2017 Assessing the Burden of Illness of Generalised Refractory Myasthenia Gravis in England, using the CPRD database
15/12/2017 The risk of myotoxicity, hepatotoxicity and acute pancreatitis in statin-exposed heart failure patients with or without concomitant use of sacubitril/valsartan - a case-control study using data of the Clinical Practice Research Datalink
08/12/2017 Risk of nephrotic syndrome among non-steroidal anti-inflammatory drug users: a population-based study in the United Kingdom
27/11/2017 Prescribing patterns of glucosamine containing products- a study using CPRD
27/11/2017 Healthcare Resource Utilization and Costs among Patients with and without Infection after Intramedullary Nailing for A Tibial Shaft Fracture
24/11/2017 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 1 - Replication of "Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study"
24/11/2017 Treatment Patterns and Characteristics of Patients with Uterine Fibroids in the UK: A Retrospective Cohort Study
22/11/2017 Outcomes following empirical antibiotic treatment of suspected urinary tract infection in older people in primary care.
21/11/2017 An exploratory study on the consistency and temporal variation of renal function of T2DM patients over time.
17/11/2017 Exploratory study of cardiovascular risk in early type 2 diabetes
17/11/2017 Metabolic effects in children and adolescents treated with psychotropic medication in primary care
03/11/2017 Estimation of the proportion of paediatric, adolescent and adult asthma patients according to modified GINA guidelines
30/10/2017 Degree of serotonin reuptake inhibition of antidepressants and the risk of ischaemic stroke and myocardial infarction: a nested case control study
30/10/2017 A UK population-based cohort study of risk factors for premature death in epilepsy
27/10/2017 The association between continuity of primary care and mortality and emergency hospitalisation for older patients with complex multimorbidity
23/10/2017 Natural History of Atrial Fibrillation in the United Kingdom