Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
15/05/2018 Is seasonal influenza vaccine effectiveness reduced in people receiving repeat vaccinations? A retrospective cohort study using the Clinical Practice Research Database
15/05/2018 Developing indicators for failure or delays in recognising clinical deterioration and escalation of care across primary care
15/05/2018 The association between inflammatory markers measured in blood and incident seizures
04/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 10 - Replication of "Prevalence and Burden of Breathlessness in Patients with Chronic Obstructive Pulmonary Disease Managed in Primary Care"
04/05/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 5 - Replication of "Pioglitazone use and risk of bladder cancer: population based cohort study"
02/05/2018 Describing the Cumulative Anticholinergic Burden in Patients Over the Age of 65, With Overactive Bladder, and the Association to Healthcare Resource Utilization. A Retrospective Observational Study Using UK Electronic Medical Records (EMR) data.
02/05/2018 Impact of removing Quality and Outcomes Framework financial incentives from English Primary Care
30/04/2018 The impact of type 2 diabetes on survival in patients with cancer independent of its effect on survival in individuals without cancer: a matched cohort analysis
30/04/2018 The epidemiology and healthcare burden of opioid therapy in the United Kingdom
30/04/2018 Health care use and cost trajectories of people in the last year of life : improving planning and resource allocation in end of life care
26/04/2018 5-ASA in Crohn's Disease: The CROHN'S Investigation (Clinical and treatment Resource use, patient Outcomes and Health impact using National prescribing Systems)
26/04/2018 Blood Eosinophil Levels and Severe Asthma Exacerbations Among Paediatric Patients with Asthma in the English Primary Care Setting
25/04/2018 Mapping opportunities for earlier detection of Bipolar Disorder - Linking big data to improve patient outcomes (MOBILISE)
25/04/2018 Unmet Needs, Symptom Burden, and Health Care Utilisation of Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Respiratory Maintenance Therapy in the United Kingdom (UK)
20/04/2018 Management of hyperthyroidism in pregnancy; data from a large UK primary care cohort
20/04/2018 Identifying and Evaluating Modifiers of Subsequent Event Risk among Patients with Established Coronary Heart Disease
18/04/2018 Cessation of renin-angiotensin system inhibitors after acute kidney injury and outcome
18/04/2018 A retrospective observational study describing the health impact of SABA over-prescription and ICS under-prescription among asthma patients
18/04/2018 Meeting the physical healthcare needs of people with serious mental illness in primary care
18/04/2018 Pharmaco-Epidemiological Study of Cardio-Respiratory Safety of Beta2-agonists for the Treatment and Management of Asthma-COPD Overlap Syndrome