Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
18/03/2019 Data analysis of the current treatments for major depressive disorder and treatment resistant depression in the United Kingdom
13/03/2019 Bereavement amongst those with chronic kidney disease - does it affect outcomes?
13/03/2019 Delayed treatment intensification and risk of micro- and macrovascular complications in insulin-treated patients with type 2 diabetes; a United Kingdom Clinical Practice Research Datalink Retrospective Cohort Study
13/03/2019 Epidemiology of Endometriosis in the Adolescent Population
12/03/2019 Database - Prescription Event Monitoring (D-PEM) study to identify, quantify and characterise identified adverse events associated with the use of a widely prescribed medication in primary care in the UK
12/03/2019 Determining the optimal timing of triple therapy initiation in patients with chronic obstructive pulmonary disease (COPD) in the United Kingdom (UK): A retrospective, longitudinal cohort study
11/03/2019 A matched population-based case control study to determine which clinical features are associated with the inherited cardiac conditions, bicuspid aortic valve and long QT syndrome in primary care
07/03/2019 Cardiovascular disease in a general asthma population: UK population study
07/03/2019 A personalized approach to depression care: Discovering adaptive treatment strategies
28/02/2019 Epidemiology and treatment pathways of ankylosing spondylitis: a retrospective UK database analysis
27/02/2019 Levothyroxine for the Treatment of Subclinical Hypothyroidism in Pregnancy: A Population-based Assessment
22/02/2019 The association between fracture risk and diabetes duration, complications and regulation in diabetes mellitus
22/02/2019 Comparability of characteristics of lung cancer patients in the UK and NSCLC patients included in phase III clinical trials that evaluated targeted therapies or immunotherapy
22/02/2019 Understanding the harms of antihypertensives, statins and antiplatelets for prevention of cardiovascular disease: A prognostic modelling and casual inference study
21/02/2019 Characterisation and natural history of non-exacerbating chronic obstructive pulmonary disease patients in a general practice-based population
21/02/2019 The impact of musculoskeletal conditions on outcome of hospital care for acute coronary syndrome and stroke: a linked electronic health record study
14/02/2019 Comparative safety profile of antidiabetic drug regimens containing SGLT-2 inhibitors and/or GLP-1 receptor agonists among type 2 diabetes patients
12/02/2019 What are the optimal blood pressure targets for patients in atrial fibrillation treated with non-vitamin K antagonist oral anticoagulants?
12/02/2019 Use of Sodium-glucose co-transporter-2 inhibitors, changes in body mass index and risk of major osteoporotic fracture
11/02/2019 The weight loss effects of glucagon-like peptide-1 receptor agonists and the risk of breast cancer in women with type 2 diabetes