Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
11/02/2019 Utilization, Effectiveness, and Safety of SGLT2 Inhibitors Among Patients with Type 2 Diabetes Mellitus
08/02/2019 Treatment pathways to severe asthma and health care resource utilisation in the UK
08/02/2019 Investigating the extent to which exposure to varicella boosts Varicella zoster virus-immunity: a self-controlled case-series, 1997-2018
08/02/2019 Trends in incidence of first diabetic foot ulcer and mortality in patients with T1 AND T2 DM
08/02/2019 Risks of antidepressants on cardiovascular mortality and morbidity, suicidality, falls and fractures in people with obesity and depression in primary care
05/02/2019 Type 2 Diabetes in women after a diagnosis of gestational diabetes: understanding uptake to screening and progression rates- a retrospective cohort study in the CPRD database
05/02/2019 The association of cancer and autism spectrum condition in a UK population
01/02/2019 Characterising end of life health care expenditure
29/01/2019 Incidence of major adverse cardiovascular and cerebrovascular events (MACE) in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis: a retrospective analysis of a United Kingdom database
29/01/2019 Fractured wrist; predictors of poor long-term clinical and socioeconomic outcomes (The FILTER Study)
25/01/2019 Inflammatory Skin Diseases and the Risk of Chronic Kidney Disease - Cross-sectional and Cohort Studies
24/01/2019 C-reactive protein as a biomarker of response to inhaled corticosteroids in COPD
22/01/2019 Life-Limiting Conditions: the health of children and their Mothers
17/01/2019 Identifying predictors of drug treatment response in bipolar disorder
17/01/2019 Dose adjustment or discontinuous use of direct oral anticoagulants related to the concurrent use of potential interacting drugs
17/01/2019 Effectiveness of long acting muscarinic-antagonist- (LAMA) as an add-on to inhaled corticosteroids / long acting beta-agonists (LABA) in smoking asthmatics
17/01/2019 Recording of anxiety diagnoses and symptoms in primary care and trends in prescribing for anxiety
10/01/2019 The influence of the number of concomitant drugs used, on the safety and efficacy of NOACs compared to warfarin in patients with atrial fibrillation treated in routine care
10/01/2019 Understanding the Relationship between Multimorbidity in Later Life, Use of Health Services and Costs of Health Care (MuSeCol)
10/01/2019 Guideline discordant diagnostic care: when do primary care referrals not reflect guidelines for suspected cancer?