Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
23/10/2017 The impact of polypharmacy on health outcomes in older patients: a retrospective cohort study using CPRD database.
18/10/2017 The health care use and cost of care before and after the diagnosis of six selected endocrine diseases in UK patients
17/10/2017 Real-world comparison of Qvar BAI versus Qvar MDI and all beclometasone MDI for the treatment of asthma based on a UK retrospective database study.
12/10/2017 Primary care prescriptions of nephrotoxic medications in children with a previous episode of acute kidney injury or with a diagnosis of chronic kidney disease
11/10/2017 The adverse effects of tramadol
09/10/2017 Healthcare resource utilization among patients diagnosed with Systemic Sclerosis-associated Interstitial Lung Disease in the United Kingdom: An observational study using the Clinical Practice Research Datalink - INTERSTELLAR
06/10/2017 Treatment of venous thromboembolism in England: an observational cohort study using Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics databases
05/10/2017 Derivation and validation of a clinical algorithm to predict patient cholesterol response to the initiation of statins and cardiovascular outcomes.
29/09/2017 Association between the prevalence of cardiovascular risk factors and new use of testosterone
29/09/2017 Cardiovascular Outcomes and Mortality in Cardio-Renal-Metabolic Disease Progression in Type 2 Diabetes Mellitus Patients within the United Kingdom
19/09/2017 the safety and effectiveness of direct oral anticoagulants antagonists in conditions that elevate drug concentrations
18/09/2017 National patterns in anti-asthmatic treatment in general practice: a descriptive study using data from the Clinical Practice Research Datalink.
13/09/2017 Effect of major common infections on the incidence of post-stroke dementia: a cohort study using the UK Clinical Practice Research Datalink
13/09/2017 Treatment with DPP-4 inhibitors, adherence to Summary of Product Characteristics and therapy adjustment.
13/09/2017 Quantifying the severity of chronic conditions in English Primary Care using the Clinical Practice Research Datalink
06/09/2017 Handling missing covariate data and changes in exposure status:
01/09/2017 Evaluation of Disease Burden and Treatment Patterns in Postpartum Depression: A Retrospective Observational Study of UK Practice
01/09/2017 Epidemiology of Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) in England: a retrospective observational study using CPRD-HES linked data
31/08/2017 Use of dipeptidyl deptidase-4 inhibitors and new-onset rheumatoid arthritis in patients with type 2 diabetes.
31/08/2017 Children and Adolescents with PaRental mental Illness: Understanding the 'who' and the 'how' of targetting interventions? 'CAPRI'