Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
15/05/2019 Psoriasis and the risk of cancer incidence and mortality: a cohort study
15/05/2019 Hypertension detection and cardiovascular outcomes: a retrospective cohort study using data from the Clinical Practice Research Datalink database
09/05/2019 Development and internal validation of prognostic scores for risk of diabetic foot ulceration
08/05/2019 Concomitant use of oral glucocorticoids and proton pump inhibitors, and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study
08/05/2019 Determinants of blood pressure lowering treatment prescribing for primary prevention: a cohort study in UK primary care
03/05/2019 An evaluation of patient outcomes for Type 2 Diabetes Mellitus (T2DM) patients prescribed dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors or Sulphonylureas (SUs) at first intensification
01/05/2019 The Use of Anti-Estrogens and the Risk of Parkinson's Disease
01/05/2019 Does anticoagulant choice affect the risk of incident dementia among individuals with atrial fibrillation? A cohort study using linked CPRD-HES data
26/04/2019 Prediction of imminent fracture risk in new users of oral bisphosphonates or recently fractured subjects: a multinational European real-world cohort study
18/04/2019 Describing the characteristics of patients who die of COPD with no evidence of prior diagnosis
18/04/2019 Safety of five years of pertussis vaccination in pregnancy in England: a cohort study
15/04/2019 Maternal post-natal GP checks: exploring the equity of care provision in England
04/04/2019 Differences in risk of long-term cardiovascular and renal outcomes between men and women after a reduction in kidney function following initiation of a renin-angiotensin system inhibitor
04/04/2019 Effectiveness on blood pressure of a switch from a monotherapy amlodipine 5 mg toward a combination amlodipine 5 mg/ bisoprolol 5 mg versus a switch toward a monotherapy amlodipine 10 mg. A cohort study using the United Kingdom CPRD
02/04/2019 Hydroxychloroquine and screening for risk of ocular toxicity - how big is the problem? Epidemiology of hydroxychloroquine prescriptions in the UK Clinical Practice Research Datalink
02/04/2019 Influence of allopurinol use on hepatotoxicity risk with thiopurine use among adults and paediatrics: a retrospective population-based cohort study
02/04/2019 An investigation into the association of asthma and fractures
01/04/2019 Cardiovascular risk prediction in daily practice: can machine-learning based risk prediction models improve the accuracy of risk prediction for individual patients?
29/03/2019 The risk of muscular events in new users of individual hydrophilic versus lipophilic statins at equivalent doses: An observational cohort study
29/03/2019 Risk of non-melanoma skin cancer among hypertensive adults in the United Kingdom treated with angiotensin converting enzyme inhibitors: a population based, active comparator, new user, retrospective cohort study