Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

 

ISAC Approval Date Title
24/07/2018 Understanding the impact of the routine use of anti-diabetic (PPAR gamma)/anti-hyperlipidaemic (PPAR alpha) medication on risk of brain tumours and case fatality
24/07/2018 Determining the frequency of abnormal hepatic fibrosis measures and liver cirrhosis/decompensation in UK primary care
23/07/2018 Evaluating effect modification using propensity score matching and disease risk score methods: an empirical study
23/07/2018 Long term impact of giving antibiotics before skin incision versus after cord clamping on children born by caesarean section: longitudinal study based on UK electronic health records
20/07/2018 Serum cholesterol trajectories in the years prior to lymphoma diagnosis
20/07/2018 Using electronic health records to assess effectiveness of national policy in dementia recognition in the UK
20/07/2018 Dipeptidyl peptidase-4 inhibitors and the risk of bullous pemphigoid among patients with type 2 diabetes
16/07/2018 Correlation of forced expiratory volume in one second with mortality and resource use in patients with asthma
16/07/2018 Risk factors of cardiovascular disease amongst users of anti-osteoporosis therapy/ies, patients with osteoporosis, or those suffering a fracture in the UK NHS: a cohort study
12/07/2018 Describing monotherapy and combination use in male and female patients with treatment for Lower Urinary Tract Symptoms. A retrospective, observational study using the UK CPRD
12/07/2018 Drug utilisation among primary care patients with knee osteoarthritis (KOA): a population-based study using CPRD
10/07/2018 The extent of medication complexity in general practice
10/07/2018 The combine effect of renin angiotensin aldosterone system blockage and Sodium-glucose co-transporter-2 receptor inhibition on renal outcomes in type 2 diabetes
09/07/2018 Impact of ethnicity on the development of kidney disease in the UK, a retrospective database study
09/07/2018 Risk Stratification and multimorbidity in Chronic Obstructive Pulmonary Disease (COPD)
04/07/2018 A cohort study investigating the association of flucloxacillin and liver injury within people previously exposed to the drug
04/07/2018 Prognostic relevance of severe hypoglycaemia and factors associated with poor outcomes in subjects experiencing severe hypoglycaemia
28/06/2018 Risk factors for overtreatment and undertreatment of glucose-control in patients with diabetes mellitus and association of overtreatment with mortality
22/06/2018 Prevalence, incidence, and natural history of gastroparesis in the United Kingdom: real world evidence from the Clinical Practice Research Datalink
20/06/2018 The impact of not speaking English as a first language on diabetes control and outcomes in primary care