Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
23/02/2018 Real-World Evidence in Oncology in England: Epidemiology, Patient Characteristics and Survival
19/02/2018 Characteristics of patients initiating and switching oral anticoagulants (OACs) for non-valvular atrial fibrillation (NVAF) in the UK general practices
19/02/2018 Distribution of COPD patients by COPD GOLD Classification and their primary health-care and respiratory medication utilization in the Clinical Practice Research Datalink (CPRD)
15/02/2018 Risk and clinical impact of nontuberculous mycobacterial disease (NTM) within the general and chronic respiratory disease UK primary care patient populations, 2006-2016.
15/02/2018 Investigating pregnancies without recorded outcomes in the Clinical Practice Research Datalink / London School of Hygiene and Tropical Medicine Pregnancy Register, with the aim of improving validity.
14/02/2018 Is patient-level achievement of primary care diabetes targets associated with emergency hospital admissions or mortality among the population with type 2 diabetes? A national observational study.
13/02/2018 Risk of Serious Infections in Patients with Psoriasis: a Cohort Study using the Clinical Practice Research Datalink
13/02/2018 Epidemiology of von Willebrand Disease in the UK (1989-2016): Prevalence, treatment patterns, descriptive characteristics, and incidence and prevalence of various outcomes and co-morbidities based on routine clinical care.
13/02/2018 Determining profiles of musculoskeletal health using electronic health records
08/02/2018 Chronic kidney disease stage G3-G5 and the risk of subsequent fractures after hip fracture
06/02/2018 Incretin-based drugs and the incidence of cholangiocarcinoma among patients with type 2 diabetes.
06/02/2018 Completion of Recommended Hepatitis Vaccination Schedules Among Adults in the United Kingdom
05/02/2018 Aripiprazole and risk of psychiatric treatment failure
05/02/2018 Prevalence of gas trapping in COPD - estimation from spirometry
30/01/2018 The risk of angioedema and other specific safety events of interest in association with use of sacubitril/valsartan in adult patients with heart failure - a cohort study
24/01/2018 Feasibility study to establish the value of linked CPRD and HES data to support medical device vigilance
24/01/2018 Epidemiology study of Invasive Extra-Intestinal pathogenic Escherichia coli (ExPEC) Disease in adults and elderly using real world healthcare databases
22/01/2018 Partner bereavement and subsequent diagnosis of specific skin diseases
17/01/2018 Cardiovascular and cerebrovascular safety of testosterone replacement therapy in hypogonadal men
17/01/2018 Lifestyle and socio-economic risk factors for non-valvular atrial fibrillation