Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
07/06/2017 Validation of algorithm for determining opposite-sex partners in the Clinical Practice Research Datalink with an exploratory analysis in same-sex partners
06/06/2017 To assess whether landmarking and/or latent classes are better than traditional methods for assessing the relationship between changes in lung function (FEV1) over time and mortality in a primary care COPD cohort with multiple co-morbidities
06/06/2017 Development and validation of clinical prediction rules to help with decision making and early detection of multiple myeloma
02/06/2017 Safety and Effectiveness of Direct Oral Anticoagulants and Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation; A Multi-Database Cohort Study with Meta-Analysis
31/05/2017 Comparison of real world outcomes of HF patients in the UK and the USA
25/05/2017 Zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in elderly in England
24/05/2017 Changes in cause of mortality over time in people with chronic respiratory disease in the UK
24/05/2017 Association between diabetes control and risk of fractures: a follow-up and a nested case control
23/05/2017 Retrospective Comparative Effectiveness Study Assessing Treatment and Rates of Exacerbation among Chronic Obstructive Pulmonary Disease Subjects in England
19/05/2017 The use and protective effect of antibiotics against complications of infection in patients in primary care: a cohort study using linked data from CPRD, HES, and ONS
18/05/2017 The role of hepatitis B in the progression of Non-Alcoholic Fatty Liver Disease (NAFLD) in type 2 diabetes melltius (T2DM) patients.
16/05/2017 Comorbidity as a predictor of referral to, and outcome from, joint replacement surgery in primary care patients with newly diagnosed arthritis: a population-based cohort study
16/05/2017 Association between glycated hemoglobin (HbA1c), weight and hypoglycemia to treatment choice and medication adherence in Type 2 Diabetes Mellitus (T2DM)
12/05/2017 Uptake and effectiveness of the seasonal trivalent influenza vaccine in autoimmune inflammatory rheumatic disease patients receiving corticosteroids and disease modifying anti-rheumatic drugs
12/05/2017 Life-Limiting Conditions in Children and Young People: Prevalence and GP involvement
11/05/2017 Development and validation of multimorbidity scores for health services outcomes
10/05/2017 Characterization of Chronic Obstructive Pulmonary Disease (COPD) patients initiating inhaled triple therapy in the United Kingdom
09/05/2017 The risk of depression and anxiety in adults diagnosed with vitiligo compared to the general population, in the UK
09/05/2017 Parkinson's disease and the risk of epileptic seizures - cohort study with nested case-control analysis
02/05/2017 Predicting prostate cancer progression: Associations between routine primary care data and prostate cancer outcomes.