Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
18/06/2019 What happens between first symptoms and first acute exacerbation of COPD? Mapping and prediction study
18/06/2019 Stroke incidence among people with heart failure and atrial fibrillation
12/06/2019 Potentially unintended discontinuation of medication following hospitalisation: a retrospective cohort study
12/06/2019 Treatment patterns among new users of maintenance asthma medications in the United Kingdom
12/06/2019 Thiazide Diuretics and the Risk of Colorectal Cancer: A Population-Based Cohort Study
06/06/2019 Trends in diabetes-related complications and cause of death in patients with diabetes in England
06/06/2019 An observational, retrospective, matched case-control study to assess the effectiveness of Priorix vaccine in children born after 2004 in the United Kingdom (UK)
31/05/2019 Temporal trends in the incidence of autism spectrum disorder in children and variation in diagnosis rates: A retrospective study using UK electronic medical records
31/05/2019 An observational study to establish the cardiovascular-renal-metabolism comorbidity epidemiology and healthcare utilisation in England
31/05/2019 Trends in cancer incidence and mortality in people with pre-diabetes and diabetes among different ethnicities
29/05/2019 Anticholinergic antidepressant drugs and long-term risk of dementia
29/05/2019 An exploratory study of antibiotic prescribing in the CPRD Aurum database
29/05/2019 Using routinely collected healthcare data to predict onset of AF and determine subsequent disease trajectories
23/05/2019 Nature and duration of lipid modifying therapy prescription in response to potential statin intolerance in the UK: an observational study
23/05/2019 Utilization, safety and effectiveness of pharmacological therapy in gestational diabetes
23/05/2019 Herpes zoster vaccine and the risk of Bell's palsy and Guillain-Barre Syndrome in the UK
22/05/2019 The effect of smoking on BMI amongst COPD patients compared with controls: a retrospective cohort study using the CPRD GOLD database
22/05/2019 Assessment of Long-Term Bowel Dysfunction in Rectal Cancer Survivors - A Population-Based Cohort Study
22/05/2019 Effect of Long-Term Exposure to Anticholinergic Drugs on Dementia, an Emulated Target Trial
21/05/2019 Non-steroidal anti-inflammatory drug use and the risk of revision of lower joint replacement: A retrospective cohort study