Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
10/01/2019 Mapping the opportunities for earlier diagnosis and characterising the management costs of psoriasis and impact of key co-morbidities
10/01/2019 Are beta blockers beneficial or harmful in obstructive sleep apnoea?
02/01/2019 An epidemiological study to compare adverse events associated with different formulations of latanoprost
21/12/2018 Defining different recovery trajectories following acute infections as a measure of frailty
21/12/2018 Clinical features of giant cell arteritis (GCA): An observational study using linked electronic primary and secondary care medical records
21/12/2018 The pattern of incident fractures in patients with diabetes mellitus compared to matched controls
19/12/2018 Withdrawal of historical inhaled corticosteroids in primary care using electronic records
19/12/2018 Testing a data-based definition of severity in atopic dermatitis in a linked primary and secondary care dataset in England: Implications on clinical outcomes and healthcare resource use
19/12/2018 A study using Observational Health Data Sciences and Informatics tools to characterize treatment pathways for stroke prevention in Atrial Fibrillation across diverse population settings (TxPath-AF)
19/12/2018 Understanding the predictive values of symptoms, prescriptions, and investigation patterns for cancer and non-neoplastic disease in primary care consultees
19/12/2018 A personalized dynamic blood pressure control plan for patients with hypertension to maximize the delay of cardiovascular events
19/12/2018 The Health Economic Burden of Atopic Dermatitis and Associated Dermatologic Conditions: A Study of Cow's Milk Allergy (CMA) in patients > 5 years of age in the Primary and Secondary Care Pathways
14/12/2018 Translation of the electronic Frailty Index for use with the International Statistical Classification of Diseases and Related Health Problems tool in hip and knee replacement patients
11/12/2018 All-cause and cardio-renal-metabolic mortality in people with or without type 2 diabetes: a comparative international trend study
11/12/2018 The Costs and Complications of Colostomy, Ileostomy and Urostomy in England in Primary and Secondary Care: A 10-Year Study using Real World Datasets
11/12/2018 Mental illness: changes in incidence, prevalence, treatment and outcomes 2000-2018
11/12/2018 Evaluating the risk of macrovascular events, disability, and mortality in individuals with multiple sclerosis in England: a population-based retrospective cohort study
11/12/2018 Identifying population groups at risk of avoidable hospitalisations for community acquired pneumonia in the UK.
11/12/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 3 -Replication of "Non-persistence and non-adherence of patients with Type 2 Diabetes Mellitus in Therapy with GLP-1 Receptor Agonists: A Retrospective Analysis"
05/12/2018 Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 20 - Replication of "Risk of Death and Cardiovascular Outcomes with Thiazolidinediones: A Study with the General Practice Research Database and Secondary Care Data"