Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Protocols below are listed in order of date of approval. Please click on the study title for more details.

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page


ISAC Approval Date Title
10/09/2018 Characterization of acute coronary syndrome patients that switch from dual antiplatelet therapy to monotherapy with clopidogrel or aspirin
10/09/2018 Referral rates of severe asthma patients to asthma specialists in the UK and the impact on healthcare use
10/09/2018 Initiation of Combination Therapy in Type 2 Diabetes Patients with high HbA1c at diagnosis
10/09/2018 Sodium-glucose co-transporter 2 inhibitors and the risk of fractures in patients with type 2 diabetes
10/09/2018 Mortality trends in people with and without type 2 diabetes in UK: a CPRD observational study
29/08/2018 Age at onset of multiple cardiovascular disease conditions: differences in ethnic subgroups by diabetes status
29/08/2018 The burden of incontinence of urine associated with prostate cancer treatment: documenting the prevalence and highlighting the difference between prostate cancer treatment modalities
29/08/2018 The relationship between partner bereavement and being diagnosed with dementia
29/08/2018 A study to evaluate growth characteristics and burden of illness in patients with achondroplasia
22/08/2018 Prediction of anticoagulation control and associated health economic outcomes in patients with atrial fibrillation (AF) managed on warfarin
22/08/2018 The role of CA125 in the detection of ovarian cancer in symptomatic primary care patients
22/08/2018 Assessing the Burden of Allergy Management in England
22/08/2018 Testosterone replacement therapy and the risk of prostate cancer in men with age-related hypogonadism
20/08/2018 Comparative Safety of the Sodium Glucose Co-transporter-2 (SGLT2) Inhibitors in Patients with Type 2 Diabetes
14/08/2018 Do systemic antibiotics affect the effectiveness of chemotherapy for malignant cancers? - A cohort study based on CPRD and Cancer Registry data
09/08/2018 An assessment of CPRD Aurum data quality
09/08/2018 Is polypharmacy associated with death or ischemic stroke in individuals newly diagnosed with atrial fibrillation? A prognostic cohort study using data from The Clinical Practice Research Datalink (CPRD)
08/08/2018 Fractures in people with intellectual disabilities: comparison with the general population and development of a fracture risk calculator specific to these patients
07/08/2018 Relationship between Body Mass Index (BMI) trajectory and the risk of cardiovascular disease and diabetes among overweight and obese people: A UK Primary Care-based cohort study
07/08/2018 M.A.P.P.E.D. IMproving the Accuracy of Psychosis PrEDiction using primary-care consultation data