Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
25/04/2018 Unmet Needs, Symptom Burden, and Health Care Utilisation of Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Respiratory Maintenance Therapy in the United Kingdom (UK)
20/04/2018 Identifying and Evaluating Modifiers of Subsequent Event Risk among Patients with Established Coronary Heart Disease
20/04/2018 Management of hyperthyroidism in pregnancy; data from a large UK primary care cohort
18/04/2018 Cessation of renin-angiotensin system inhibitors after acute kidney injury and outcome
18/04/2018 Meeting the physical healthcare needs of people with serious mental illness in primary care
18/04/2018 A retrospective observational study describing the health impact of SABA over-prescription and ICS under-prescription among asthma patients
18/04/2018 Pharmaco-Epidemiological Study of Cardio-Respiratory Safety of Beta2-agonists for the Treatment and Management of Asthma-COPD Overlap Syndrome
18/04/2018 Antibiotic Choice in UK General Practice - rates and drivers of potentially inappropriate antibiotic type in UK general practices
11/04/2018 Epidemiology of amyloidosis in the United Kingdom
11/04/2018 Utilisation of Ulipristal acetate 5mg, long-term treatment patterns, resource utilisation in a population-based cohort in UK using the THIN and CPRD databases
09/04/2018 Understanding the physical harms associated with the use of combined antipsychotic medication in people with schizophrenia
06/04/2018 Weight change and the onset and progression of cardiovascular diseases in large scale electronic health records
05/04/2018 Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with coronary artery disease (CAD), peripheral artery disease (PAD), and CAD or PAD
05/04/2018 Abdominal pain in primary care: establishing a clinical profile and diagnostic pathway for identifying cancer
05/04/2018 Comparison of Outcomes for Patients Hospitalised for Heart Failure (HHF) in the UK, Japan, USA and Taiwan
03/04/2018 REPEAT: Study 9- Replication of "Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis"
03/04/2018 Individual-level cost-of-illness Analysis for FoResight and Modelling for European HEalth Policy and Regulation (FRESHER) Project using linked English Data
03/04/2018 Healthcare resource utilisation associated with hepatocellular carcinoma in the UK
28/03/2018 A Comparison of the Effectiveness and Safety of Direct Oral Anticoagulants (DOACs) versus. Warfarin in Older People with Atrial Fibrillation
28/03/2018 Utilisation pattern of hormonal replacement therapy in UK general practice between 2000 and 2016