Approved studies using CPRD Data

Applications to access CPRD data for observational research are reviewed by the Independent Scientific Advisory Committee (ISAC). Approval by ISAC is required for researchers to carry out their proposed studies.

A summary of all ISAC-approved protocols, including a lay and technical summary of the proposed research, is published three months after researchers have access to the data to begin their study.

The table below includes all ISAC-approved protocols submitted to CPRD from 1st July 2015. Searches can be carried out using applicant names, approval date or by using key words within the protocol title. Protocols below are listed in order of date of approval.


ISAC Approval Date Title
29/08/2017 Dipeptidyl deptidase-4 inhibitors and the incidence of inflammatory bowel disease among patients with type 2 diabetes.
23/08/2017 Use of anti-Alzheimer's disease treatments among individuals with mild cognitive impairment
22/08/2017 Association between antineoplastic therapies and venous thromboembolism in patients with active cancer
18/08/2017 Estimating heterogeneous treatment effects from routinely collected health data: A case study on anticoagulant therapy for atrial fibrillation patients.
18/08/2017 Persistence and healthcare resource utilisation in non-valvular atrial fibrillation patients treated with oral anticoagulants in England
18/08/2017 Comparative effectiveness of combination therapies in COPD
18/08/2017 Distance from glycaemic goal in patients with Type 2 Diabetes Mellitus in the UK
17/08/2017 Epidemiology of bleeding complications post-Acute Coronary Syndrome within the UK primary care setting
08/08/2017 Restriction and comorbidity matching to control for confounding in a study of 5 alpha reductase Inhibitors (5ARIs) and risk of Venous Thromboembolism (VTE) in male Benign Prostatic Hyperplasia (BPH) patients.
08/08/2017 Trends in survival of older care home residents in England since 1995: a multi-cohort study
08/08/2017 Incidence and prevalence of autoimmune hepatitis in the UK. A population-based cohort study.
08/08/2017 Risk of colorectal adenoma after obesity surgery
04/08/2017 Effectiveness of triple therapy versus dual bronchodilation in patients with chronic obstructive pulmonary disease
03/08/2017 EMERALD: Exploring Mental Illness and Diabetes through a Longitudinal Data study
03/08/2017 Alzheimer's treatment and the risk of serious adverse events
03/08/2017 Identification of high cost patients in primary and secondary care and an analysis of their utilisation patterns, and social and demographic characteristics.
03/08/2017 Utilisation of antiepileptic medicines in girls and women of childbearing potential
03/08/2017 Cardiovascular risk prediction in daily practice: are risk scores such as QRISK2 accurate enough to be used for individual patient care?
01/08/2017 Clinical profile of pre-defined asthma phenotypes in a large cohort of UK primary care patients (CPRD).