Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,500 peer-reviewed publications. The CPRD bibliography is updated on a monthly basis (last updated 6 July 2020) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


 (PDF, 3MB, 206 pages) 

This work uses data provided by patients and collected by the NHS as part of their care and support. CPRD encourages researchers to use this citation in all publications using CPRD data. Find out more about acknowledging the use of patient data at the Understanding Patient Data website



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J. Leal, Gray, A. M., Hawley, S., Prieto-Alhambra, D., Delmestri, A., Arden, N. K., Cooper, C., Javaid, M. K., and Judge, A., Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study, J Bone Miner Res, vol. 32, pp. 203-211, 2017.
L. E. Bayliss, Culliford, D., Monk, A. P., Glyn-Jones, S., Prieto-Alhambra, D., Judge, A., Cooper, C., Carr, A. J., Arden, N. K., Beard, D. J., and Price, A. J., The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study, Lancet, vol. 389, pp. 1424-1430, 2017.
A. Shah, Prieto-Alhambra, D., Hawley, S., Delmestri, A., Lippett, J., Cooper, C., Judge, A., and Javaid, M. K., Geographic variation in secondary fracture prevention after a hip fracture during 1999-2013: a UK study, Osteoporos Int, vol. 28, pp. 169-178, 2017.
D. Yu, Jordan, K. P., Bedson, J., Englund, M., Blyth, F., Turkiewicz, A., Prieto-Alhambra, D., and Peat, G., Population trends in the incidence and initial management of osteoarthritis: age-period-cohort analysis of the Clinical Practice Research Datalink, 1992-2013, Rheumatology (Oxford), vol. 56, pp. 1902-1917, 2017.
N. Arden, Altman, D., Beard, D., Carr, A., Clarke, N., Collins, G., Cooper, C., Culliford, D., Delmestri, A., Garden, S., Griffin, T., Javaid, K., Judge, A., Latham, J., Mullee, M., Murray, D., Ogundimu, E., Pinedo-Villanueva, R., Price, A., Prieto-Alhambra, D., and Raftery, J., Programme Grants for Applied Research, in Lower limb arthroplasty: can we produce a tool to predict outcome and failure, and is it cost-effective? An epidemiological study, Southampton (UK): NIHR Journals Library Copyright (c) Queen's Printer and Controller of HMSO 2017. This work was produced by Arden et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the pu, 2017.
A. Judge, Garriga, C., Arden, N. K., Lovestone, S., Prieto-Alhambra, D., Cooper, C., and Edwards, C. J., Protective effect of antirheumatic drugs on dementia in rheumatoid arthritis patients, Alzheimers Dement (N Y), vol. 3, pp. 612-621, 2017.
T. Khan, Alvand, A., Prieto-Alhambra, D., Culliford, D. J., Judge, A., Jackson, W. F., Scammell, B. E., Arden, N. K., and Price, A. J., ACL and meniscal injuries increase the risk of primary total knee replacement for osteoarthritis: a matched case-control study using the Clinical Practice Research Datalink (CPRD), Br J Sports Med, 2018.
S. Hawley, Cordtz, R., Dreyer, L., Edwards, C. J., Arden, N. K., Delmestri, A., Silman, A., Cooper, C., Judge, A., and Prieto-Alhambra, D., Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: An interrupted time-series analysis, Semin Arthritis Rheum, vol. 47, pp. 605-610, 2018.
S. Khalid, Calderon-Larranaga, S., Hawley, S., Ali, M. S., Judge, A., Arden, N., Van Staa, T., Cooper, C., Javaid, M. K., and Prieto-Alhambra, D., Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database, Clin Epidemiol, vol. 10, pp. 1417-1431, 2018.
D. Yu, Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., Edwards, J. J., Mallen, C. D., Tan, V., Ukachukwu, V., Prieto-Alhambra, D., Walker, C., and Peat, G., Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink, Ann Rheum Dis, 2018.
E. Martin-Merino, Calderon-Larranaga, A., Hawley, S., Poblador-Plou, B., Llorente-Garcia, A., Petersen, I., and Prieto-Alhambra, D., The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study, Clin Epidemiol, vol. 10, pp. 643-654, 2018.
C. Garriga, Pazianas, M., Hawley, S., Delmestri, A., Prieto-Alhambra, D., Cooper, C., and Judge, A., Oral bisphosphonate use and age-related macular degeneration: retrospective cohort and nested case-control study, Ann N Y Acad Sci, vol. 1415, pp. 34-46, 2018.
E. Martin-Merino, Petersen, I., Hawley, S., Alvarez-Gutierrez, A., Khalid, S., Llorente-Garcia, A., Delmestri, A., Javaid, M. K., van Staa, T. P., Judge, A., Cooper, C., and Prieto-Alhambra, D., Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK, Osteoporos Int, vol. 29, pp. 467-478, 2018.
E. Burn, Edwards, C. J., Murray, D. W., Silman, A., Cooper, C., Arden, N. K., Pinedo-Villanueva, R., and Prieto-Alhambra, D., Trends and determinants of length of stay and hospital reimbursement following knee and hip replacement: evidence from linked primary care and NHS hospital records from 1997 to 2014, BMJ Open, vol. 8, p. e019146, 2018.
R. J. Ferguson, Prieto-Alhambra, D., Walker, C., Yu, D., Valderas, J. M., Judge, A., Griffiths, J., Jordan, K. P., Peat, G., Glyn-Jones, S., and Silman, A. J., Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, 2018.
N. S. Nagra, Robinson, D. E., Douglas, I., Delmestri, A., Dakin, S. G., Snelling, S. J. B., Carr, A. J., and Prieto-Alhambra, D., Antibiotic treatment and flares of rheumatoid arthritis: a self-controlled case series study analysis using CPRD GOLD, Sci Rep, vol. 9, p. 8941, 2019.
K. E. Lowe, Mansfield, K. E., Delmestri, A., Smeeth, L., Roberts, A., Abuabara, K., Prieto-Alhambra, D., and Langan, S. M., Atopic eczema and fracture risk in adults: A population-based cohort study, J Allergy Clin Immunol, 2019.
S. Hawley, Edwards, C. J., Arden, N. K., Delmestri, A., Cooper, C., Judge, A., and Prieto-Alhambra, D., Descriptive epidemiology of hip and knee replacement in rheumatoid arthritis: an analysis of UK electronic medical records, Semin Arthritis Rheum, 2019.
R. Y. L. Kuo, Ng, M., Prieto-Alhambra, D., and Furniss, D., Dupuytren's disease predicts increased all-cause and cancer-specific mortality: analysis of a large cohort from the UK Clinical Practice Research Datalink, Plast Reconstr Surg, 2019.
R. Ferguson, Culliford, D., Prieto-Alhambra, D., Pinedo-Villanueva, R., Delmestri, A., Arden, N., and Bowen, C., Encounters for foot and ankle pain in UK primary care: a population-based cohort study of CPRD data, Br J Gen Pract, vol. 69, pp. e422-e429, 2019.
E. Burn, Edwards, C. J., Murray, D. W., Silman, A., Cooper, C., Arden, N. K., Prieto-Alhambra, D., and Pinedo-Villanueva, R., The impact of bmi and smoking on risk of revision following knee and hip replacement surgery: evidence from routinely collected data, Osteoarthritis Cartilage, 2019.
J. L. Rees, Shah, A., Edwards, K., Sanchez-Santos, M. T., Robinson, D. E., Delmestri, A., Carr, A., Arden, N., Lamb, S. E., Rangan, A., Judge, A., Pinedo-Villanueva, R., Holt, T., Hopewell, S., Prieto-Alhambra, D., and Collins, G., Treatment of first-time traumatic anterior shoulder dislocation: the UK TASH-D cohort study, Health Technol Assess, vol. 23, pp. 1-104, 2019.
[Page last reviewed 6 July 2020]