Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 July 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 185 pages)


Export 23 results:
Author Title Type [ Year(Asc)]
Filters: Author is Williams, R.  [Clear All Filters]
P. Kasteridis, Ride, J., Gutacker, N., Aylott, L., Dare, C., Doran, T., Gilbody, S., Goddard, M., Gravelle, H., Kendrick, T., Mason, A., Rice, N., Siddiqi, N., Williams, R., and Jacobs, R., Association Between Antipsychotic Polypharmacy and Outcomes for People With Serious Mental Illness in England, Psychiatr Serv, p. appips201800504, 2019.
R. E. Ghosh, Crellin, E., Beatty, S., Donegan, K., Myles, P., and Williams, R., How Clinical Practice Research Datalink data are used to support pharmacovigilance, Therapeutic Advances in Drug Safety, 2019.
H. Strongman, Williams, R., Meeraus, W., Murray-Thomas, T., Campbell, J., Carty, L., Dedman, D., Gallagher, A., Oyinlola, J., Kousoulis, A., and Valentine, J., Limitations for health research with restricted data collection from UK primary care, Pharmacoepidemiol Drug Saf, 2019.
C. Minassian, Williams, R., Meeraus, W. H., Smeeth, L., Campbell, O. M. R., and Thomas, S. L., Methods to generate and validate a Pregnancy Register in the UK Clinical Practice Research Datalink primary care database, Pharmacoepidemiol Drug Saf, vol. 28, pp. 923-933, 2019.
G. Glover, Williams, R., Tompkins, G., and Oyinlola, J., An observational study of the use of acute hospital care by people with intellectual disabilities in England, J Intellect Disabil Res, vol. 63, pp. 85-99, 2019.
R. Williams, Kothny, W., Serban, C., Lopez-Leon, S., and Schlienger, R., Pancreatic safety of vildagliptin in patients with type 2 diabetes mellitus: A European, noninterventional, postauthorization safety study, Endocrinol Diabetes Metab, vol. 2, p. e00052, 2019.
S. Padmanabhan, Carty, L., Cameron, E., Ghosh, R. E., Williams, R., and Strongman, H., Approach to record linkage of primary care data from Clinical Practice Research Datalink to other health-related patient data: overview and implications, Eur J Epidemiol, 2018.
R. Williams, van Staa, T. P., Gallagher, A. M., Hammad, T., Leufkens, H. G. M., and de Vries, F., Cancer recording in patients with and without type 2 diabetes in the Clinical Practice Research Datalink primary care data and linked hospital admission data: a cohort study, BMJ Open, vol. 8, p. e020827, 2018.
J. Ride, Kasteridis, P., Gutacker, N., Kronenberg, C., Doran, T., Mason, A., Rice, N., Gravelle, H., Goddard, M., Kendrick, T., Siddiqi, N., Gilbody, S., Dare, C. R., Aylott, L., Williams, R., and Jacobs, R., Do care plans and annual reviews of physical health influence unplanned hospital utilisation for people with serious mental illness? Analysis of linked longitudinal primary and secondary healthcare records in England, BMJ Open, vol. 8, p. e023135, 2018.
G. Glover, Williams, R., Tompkins, G., and Oyinlola, J., An observational study of the use of acute hospital care by people with intellectual disabilities in England, J Intellect Disabil Res, 2018.
H. Strongman, Christopher, S., Majak, M., Williams, R., Bahmanyar, S., Linder, M., Heintjes, E. M., Bennett, D., Korhonen, P., and Hoti, F., Pioglitazone and cause-specific risk of mortality in patients with type 2 diabetes: extended analysis from a European multidatabase cohort study, BMJ Open Diabetes Res Care, vol. 6, p. e000481, 2018.
A. Pate, Barrowman, M., Webb, D., Pimenta, J. M., Davis, K. J., Williams, R., Van Staa, T., and Sperrin, M., Study investigating the generalisability of a COPD trial based in primary care (Salford Lung Study) and the presence of a Hawthorne effect, BMJ Open Respir Res, vol. 5, p. e000339, 2018.
H. Carreira, Williams, R., Muller, M., Harewood, R., and Bhaskaran, K., Adverse mental health outcomes in breast cancer survivors compared to women who did not have cancer: systematic review protocol, Syst Rev, vol. 6, p. 162, 2017.
R. Williams, de Vries, F., Kothny, W., Serban, C., Lopez-Leon, S., Chu, C., and Schlienger, R., Cardiovascular safety of vildagliptin in patients with type 2 diabetes: A European multi-database, non-interventional post-authorization safety study, Diabetes Obes Metab, vol. 19, pp. 1473-1478, 2017.
M. Pufulete, Maishman, R., Dabner, L., Mohiuddin, S., Hollingworth, W., Rogers, C. A., Higgins, J., Dayer, M., Macleod, J., Purdy, S., McDonagh, T., Nightingale, A., Williams, R., and Reeves, B. C., Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model, Health Technol Assess, vol. 21, pp. 1-150, 2017.
G. Glover, Williams, R., Heslop, P., Oyinlola, J., and Grey, J., Mortality in people with intellectual disabilities in England, J Intellect Disabil Res, vol. 61, pp. 62-74, 2017.
A. R. Tate, Dungey, S., Glew, S., Beloff, N., Williams, R., and Williams, T., Quality of recording of diabetes in the UK: how does the GP's method of coding clinical data affect incidence estimates? Cross-sectional study using the CPRD database, BMJ Open, vol. 7, p. e012905, 2017.
W. Hollingworth, Biswas, M., Maishman, R. L., Dayer, M. J., McDonagh, T., Purdy, S., Reeves, B. C., Rogers, C. A., Williams, R., and Pufulete, M., The healthcare costs of heart failure during the last five years of life: A retrospective cohort study, Int J Cardiol, vol. 224, pp. 132-138, 2016.
C. Willame, Baril, L., van den Bosch, J., Ferreira, G. L., Williams, R., Rosillon, D., and Cohet, C., Importance of feasibility assessments before implementing non-interventional pharmacoepidemiologic studies of vaccines: lessons learned and recommendations for future studies, Pharmacoepidemiol Drug Saf, vol. 25, pp. 1397-1406, 2016.
P. Korhonen, Heintjes, E. M., Williams, R., Hoti, F., Christopher, S., Majak, M., Kool-Houweling, L., Strongman, H., Linder, M., Dolin, P., and Bahmanyar, S., Pioglitazone use and risk of bladder cancer in patients with type 2 diabetes: retrospective cohort study using datasets from four European countries, Bmj, vol. 354, p. i3903, 2016.
S. A. Julious, Horspool, M. J., Davis, S., Bradburn, M., Norman, P., Shephard, N., Cooper, C. L., Smithson, W. H., Boote, J., Elphick, H., Loban, A., Franklin, M., Kua, W. S., May, R., Campbell, J., Williams, R., Rex, S., and Bortolami, O., PLEASANT: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term - a cluster randomised controlled trial and economic evaluation, Health Technol Assess, vol. 20, pp. 1-154, 2016.
[Page last reviewed 4 July 2019]