Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 5 August 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 187 pages)


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Author [ Title(Desc)] Type Year
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A. R. Tate, Nicholson, A., and Cassell, J. A., Are GPs under-investigating older patients presenting with symptoms of ovarian cancer? Observational study using General Practice Research Database, Br J Cancer, vol. 102, pp. 947-51, 2010.
C. Rudisill, Charlton, J., Booth, H. P., and Gulliford, M. C., Are healthcare costs from obesity associated with body mass index, comorbidity or depression? Cohort study using electronic health records, Clin Obes, vol. 6, pp. 225-31, 2016.
T. R. Card, Siffledeen, J., and Fleming, K. M., Are IBD patients more likely to have a prior diagnosis of irritable bowel syndrome? Report of a case-control study in the General Practice Research Database, United European Gastroenterol J, vol. 2, pp. 505-12, 2014.
E. C. Somers, Thomas, S. L., Smeeth, L., and Hall, A. J., Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder?, Am J Epidemiol, vol. 169, pp. 749-55, 2009.
T. P. van Staa, Bishop, N., Leufkens, H. G., and Cooper, C., Are inhaled corticosteroids associated with an increased risk of fracture in children?, Osteoporos Int, vol. 15, pp. 785-91, 2004.
I. M. Carey, Anderson, H. R., Atkinson, R. W., Beevers, S. D., Cook, D. G., Strachan, D. P., Dajnak, D., Gulliver, J., and Kelly, F. J., Are noise and air pollution related to the incidence of dementia? A cohort study in London, England, BMJ Open, vol. 8, p. e022404, 2018.
A. Ruigomez, Rodriguez, L. A. Garcia, Dev, V. J., Arellano, F., and Raniwala, J., Are schizophrenia or antipsychotic drugs a risk factor for cataracts?, Epidemiology, vol. 11, pp. 620-3, 2000.
D. Millson, Frischer, M., Croft, P., and Goadsby, P. J., Are triptans with enhanced lipophilicity used for the acute treatment of migraine associated with an increased consulting rate for depressive illness?, Cephalalgia, vol. 20, pp. 732-7, 2000.
F. Khosrow-Khavar, Yin, H., Barkun, A., Bouganim, N., and Azoulay, L., Aromatase inhibitors and the risk of colorectal cancer in postmenopausal women with breast cancer, Ann Oncol, vol. 29, pp. 744-748, 2018.
A. Ruigomez, Brauer, R., Rodriguez, L. A., Huerta, C., Requena, G., Gil, M., de Abajo, F., Downey, G., Bate, A., Tepie, M. F., de Groot, M., Schlienger, R., Reynolds, R., and Klungel, O., Ascertainment of acute liver injury in two European primary care databases, Eur J Clin Pharmacol, vol. 70, pp. 1227-35, 2014.
A. J. Walker, Grainge, M. J., and Card, T. R., Aspirin and other non-steroidal anti-inflammatory drug use and colorectal cancer survival: a cohort study, Br J Cancer, vol. 107, pp. 1602-7, 2012.
A. Leite, Andrews, N. J., and Thomas, S. L., Assessing recording delays in general practice records to inform near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD), Pharmacoepidemiol Drug Saf, vol. 26, pp. 437-445, 2017.
R. J. Pitman, Melegaro, A., Gelb, D., Siddiqui, M. R., Gay, N. J., and Edmunds, W. J., Assessing the burden of influenza and other respiratory infections in England and Wales, J Infect, vol. 54, pp. 530-8, 2007.
R. R. Camejo, McGrath, C., Herings, R., Starkie, H., and Rutten, F., Assessing the determinants of the potential for cost-effectiveness over time: the empirical case of COPD, Value Health, vol. 16, pp. 426-33, 2013.
J. D. Chalmers, Poole, C., Webster, S., Tebboth, A., Dickinson, S., and Gayle, A., Assessing the healthcare resource use associated with inappropriate prescribing of inhaled corticosteroids for people with chronic obstructive pulmonary disease (COPD) in GOLD groups A or B: an observational study using the Clinical Practice Research Data, Respir Res, vol. 19, p. 63, 2018.
M. Frisher, Crome, I., Martino, O., and Croft, P., Assessing the impact of cannabis use on trends in diagnosed schizophrenia in the United Kingdom from 1996 to 2005, Schizophr Res, vol. 113, pp. 123-8, 2009.
M. Z. Ankarfeldt, Thorsted, B. L., Groenwold, R. H., Adalsteinsson, E., Ali, M. S., and Klungel, O. H., Assessment of channeling bias among initiators of glucose-lowering drugs: A UK cohort study, Clin Epidemiol, vol. 9, pp. 19-30, 2017.
C. E. Koro, Fedder, D. O., L'Italien, G. J., Weiss, S. S., Magder, L. S., Kreyenbuhl, J., Revicki, D. A., and Buchanan, R. W., Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study, Bmj, vol. 325, p. 243, 2002.
V. Balinskaite, Bou-Antoun, S., Johnson, A. P., Holmes, A., and Aylin, P., An assessment of potential unintended consequences following a national antimicrobial stewardship programme in England: an interrupted time series analysis, Clin Infect Dis, 2018.
C. E. Koro, Fedder, D. O., L'Italien, G. J., Weiss, S., Magder, L. S., Kreyenbuhl, J., Revicki, D., and Buchanan, R. W., An assessment of the independent effects of olanzapine and risperidone exposure on the risk of hyperlipidemia in schizophrenic patients, Arch Gen Psychiatry, vol. 59, pp. 1021-6, 2002.
C. R. Meier, Schmitz, S., and Jick, H., Association between acetaminophen or nonsteroidal antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer, Pharmacotherapy, vol. 22, pp. 303-9, 2002.
S. Hajat, Haines, A., Atkinson, R. W., Bremner, S. A., Anderson, H. R., and Emberlin, J., Association between air pollution and daily consultations with general practitioners for allergic rhinitis in London, United Kingdom, Am J Epidemiol, vol. 153, pp. 704-14, 2001.
P. Kasteridis, Ride, J., Gutacker, N., Aylott, L., Dare, C., Doran, T., Gilbody, S., Goddard, M., Gravelle, H., Kendrick, T., Mason, A., Rice, N., Siddiqi, N., Williams, R., and Jacobs, R., Association Between Antipsychotic Polypharmacy and Outcomes for People With Serious Mental Illness in England, Psychiatr Serv, p. appips201800504, 2019.
G. Nakafero, Sanders, R. D., Nguyen-Van-Tam, J. S., and Myles, P. R., Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, vol. 24, pp. 793-802, 2015.
G. Nakafero, Sanders, R. D., Nguyen-Van-Tam, J. S., and Myles, P. R., The association between benzodiazepines and influenza-like illness-related pneumonia and mortality: a survival analysis using UK Primary Care data, Pharmacoepidemiol Drug Saf, vol. 25, pp. 1263-1273, 2016.
Y. B. Brauchli, Jick, S. S., Curtin, F., and Meier, C. R., Association between beta-blockers, other antihypertensive drugs and psoriasis: population-based case-control study, Br J Dermatol, vol. 158, pp. 1299-307, 2008.
D. Prieto-Alhambra, Javaid, M. K., Judge, A., Murray, D., Carr, A., Cooper, C., and Arden, N. K., Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study, Bmj, vol. 343, p. d7222, 2011.
M. Kerkhof, Tran, T. N., van den Berge, M., Brusselle, G. G., Gopalan, G., Jones, R. C. M., Kocks, J. W. H., Menzies-Gow, A., Nuevo, J., Pavord, I. D., Rastogi, S., and Price, D. B., Association between blood eosinophil count and risk of readmission for patients with asthma: Historical cohort study, PLoS One, vol. 13, p. e0201143, 2018.
C. R. Meier, Krahenbuhl, S., Schlienger, R. G., and Jick, H., Association between body mass index and liver disorders: an epidemiological study, J Hepatol, vol. 37, pp. 741-7, 2002.
G. Ronquist, Rodriguez, L. A., Ruigomez, A., Johansson, S., Wallander, M. A., Frithz, G., and Svardsudd, K., Association between captopril, other antihypertensive drugs and risk of prostate cancer, Prostate, vol. 58, pp. 50-6, 2004.
J. George, Majeed, W., Mackenzie, I. S., MacDonald, T. M., and Wei, L., Association between cardiovascular events and sodium-containing effervescent, dispersible, and soluble drugs: nested case-control study, Bmj, vol. 347, p. f6954, 2013.
I. Barker, Steventon, A., and Deeny, S. R., Association between continuity of care in general practice and hospital admissions for ambulatory care sensitive conditions: cross sectional study of routinely collected, person level data, Bmj, vol. 356, p. j84, 2017.
N. Dunn, Mullee, M., Perry, V. H., and Holmes, C., Association between dementia and infectious disease: evidence from a case-control study, Alzheimer Dis Assoc Disord, vol. 19, pp. 91-4, 2005.
V. Sazonov, Beetsch, J., Phatak, H., Wentworth, C., and Evans, M., Association between dyslipidemia and vascular events in patients treated with statins: report from the UK General Practice Research Database, Atherosclerosis, vol. 208, pp. 210-6, 2010.
C. L. Morgan, Mukherjee, J., Jenkins-Jones, S., Holden, S. E., and Currie, C. J., Association between first-line monotherapy with sulphonylurea versus metformin and risk of all-cause mortality and cardiovascular events: a retrospective, observational study, Diabetes Obes Metab, vol. 16, pp. 957-62, 2014.
P. A. Vissers, Cardwell, C. R., van de Poll-Franse, L. V., Young, I. S., Pouwer, F., and Murray, L. J., The association between glucose-lowering drug use and mortality among breast cancer patients with type 2 diabetes, Breast Cancer Res Treat, vol. 150, pp. 427-37, 2015.
J. Vavanikunnel, Charlier, S., Becker, C., Schneider, C., Jick, S. S., Meier, C. R., and Meier, C., Association between glycemic control and risk of fracture in diabetic patients: A nested case-control study, J Clin Endocrinol Metab, 2019.
G. Nakafero, Grainge, M. J., Myles, P. R., Mallen, C. D., Zhang, W., Doherty, M., Nguyen-Van-Tam, J. S., and Abhishek, A., Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink, Ann Rheum Dis, 2019.
S. E. Holden, Jenkins-Jones, S., and Currie, C. J., Association between Insulin Monotherapy versus Insulin plus Metformin and the Risk of All-Cause Mortality and Other Serious Outcomes: A Retrospective Cohort Study, PLoS One, vol. 11, p. e0153594, 2016.
R. Baker, Kendrick, D., Tata, L. J., and Orton, E., Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England, Inj Prev, vol. 23, pp. 396-402, 2017.
G. Davey, Sedgwick, P., Maier, W., Visick, G., Strachan, D. P., and Anderson, H. R., Association between migraine and asthma: matched case-control study, Br J Gen Pract, vol. 52, pp. 723-7, 2002.
S. Hawley, Cordtz, R., Dreyer, L., Edwards, C. J., Arden, N. K., Delmestri, A., Silman, A., Cooper, C., Judge, A., and Prieto-Alhambra, D., Association between NICE guidance on biologic therapies with rates of hip and knee replacement among rheumatoid arthritis patients in England and Wales: An interrupted time-series analysis, Semin Arthritis Rheum, vol. 47, pp. 605-610, 2018.
C. S. Chui, Chan, E. W., Wong, A. Y., Root, A., Douglas, I. J., and Wong, I. C., Association between oral fluoroquinolones and seizures: A self-controlled case series study, Neurology, vol. 86, pp. 1708-15, 2016.
A. Skow, Douglas, I., and Smeeth, L., The association between Parkinson's disease and anti-epilepsy drug carbamazepine: a case-control study using the UK General Practice Research Database, Br J Clin Pharmacol, vol. 76, pp. 816-22, 2013.
L. Wei, MacDonald, T., and Shimi, S., Association between prior appendectomy and/or tonsillectomy in women and subsequent pregnancy rate: a cohort study, Fertil Steril, vol. 106, pp. 1150-1156, 2016.
J. Spoendlin, Bichsel, F., Voegel, J. J., Jick, S. S., and Meier, C. R., The association between psychiatric diseases, psychotropic drugs and the risk of incident rosacea, Br J Dermatol, vol. 170, pp. 878-83, 2014.
F. J. de Abajo, Rodriguez, L. A., and Montero, D., Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study, Bmj, vol. 319, pp. 1106-9, 1999.
L. Alexandre, Clark, A. B., Bhutta, H. Y., Chan, S. S., Lewis, M. P., and Hart, A. R., Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study, Gastroenterology, vol. 150, pp. 854-65.e1; quiz e16-7, 2016.
W. G. Dixon, Suissa, S., and Hudson, M., The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta-analyses, Arthritis Res Ther, vol. 13, p. R139, 2011.
D. J. Margolis, Hoffstad, O., and Isseroff, R. R., Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers, Arch Dermatol, vol. 143, pp. 1275-80, 2007.
[Page last reviewed 5 August 2019]