Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 May 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2237 results:
Author Title [ Type(Desc)] Year
Book Chapter
C. D. Steer, Macleod, J., Tilling, K., Lim, A. G., Marsden, J., Millar, T., Strang, J., Telfer, M., Whitaker, H., Vickerman, P., and Hickman, M., Health Services and Delivery Research, in The impact of opiate substitution treatment on mortality risk in drug addicts: a natural experiment study, Southampton (UK): NIHR Journals Library Copyright (c) Queen's Printer and Controller of HMSO 2019. This work was produced by Steer et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely repro, 2019.
A. Judge, Javaid, M. K., Leal, J., Hawley, S., Drew, S., Sheard, S., Prieto-Alhambra, D., Gooberman-Hill, R., Lippett, J., Farmer, A., Arden, N., Gray, A., Goldacre, M., Delmestri, A., and Cooper, C., Health Services and Delivery Research, in Models of care for the delivery of secondary fracture prevention after hip fracture: a health service cost, clinical outcomes and cost-effectiveness study within a region of England, Southampton (UK): NIHR Journals Library Copyright (c) Queen's Printer and Controller of HMSO 2016. This work was produced by Judge et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the pu, 2016.
N. Arden, Altman, D., Beard, D., Carr, A., Clarke, N., Collins, G., Cooper, C., Culliford, D., Delmestri, A., Garden, S., Griffin, T., Javaid, K., Judge, A., Latham, J., Mullee, M., Murray, D., Ogundimu, E., Pinedo-Villanueva, R., Price, A., Prieto-Alhambra, D., and Raftery, J., Programme Grants for Applied Research, in Lower limb arthroplasty: can we produce a tool to predict outcome and failure, and is it cost-effective? An epidemiological study, Southampton (UK): NIHR Journals Library Copyright (c) Queen's Printer and Controller of HMSO 2017. This work was produced by Arden et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the pu, 2017.
Journal Article
S. Ratib, Fleming, K. M., Crooks, C. J., Aithal, G. P., and West, J., 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998-2009: a large population study, J Hepatol, vol. 60, pp. 282-9, 2014.
T. C. Chen, Chen, L. C., and Knaggs, R. D., A 15-year overview of increasing tramadol utilisation and associated mortality and the impact of tramadol classification in the United Kingdom, Pharmacoepidemiol Drug Saf, vol. 27, pp. 487-494, 2018.
P. Boyle, Roehrborn, C., Harkaway, R., Logie, J., de la Rosette, J., and Emberton, M., 5-Alpha reductase inhibition provides superior benefits to alpha blockade by preventing AUR and BPH-related surgery, Eur Urol, vol. 45, pp. 620-6; discussion 626-7, 2004.
L. Azoulay, Eberg, M., Benayoun, S., and Pollak, M., 5alpha-Reductase Inhibitors and the Risk of Cancer-Related Mortality in Men With Prostate Cancer, JAMA Oncol, vol. 1, pp. 314-20, 2015.
T. P. van Staa, Card, T., Logan, R. F., and Leufkens, H. G., 5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study, Gut, vol. 54, pp. 1573-8, 2005.
A. M. Walker, Szneke, P., Bianchi, L. A., Field, L. G., Sutherland, L. R., and Dreyer, N. A., 5-Aminosalicylates, sulfasalazine, steroid use, and complications in patients with ulcerative colitis, Am J Gastroenterol, vol. 92, pp. 816-20, 1997.
T. P. van Staa, Travis, S., Leufkens, H. G., and Logan, R. F., 5-aminosalicylic acids and the risk of renal disease: a large British epidemiologic study, Gastroenterology, vol. 126, pp. 1733-9, 2004.
B. L. Strom, Schinnar, R., Apter, A. J., Margolis, D. J., Lautenbach, E., Hennessy, S., Bilker, W. B., and Pettitt, D., Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics, N Engl J Med, vol. 349, pp. 1628-35, 2003.
Y. C. Chen, Wu, J. C., Haschler, I., Majeed, A., Chen, T. J., and Wetter, T., Academic impact of a public electronic health database: bibliometric analysis of studies using the general practice research database, PLoS One, vol. 6, p. e21404, 2011.
H. P. Booth, Prevost, A. T., and Gulliford, M. C., Access to weight reduction interventions for overweight and obese patients in UK primary care: population-based cohort study, BMJ Open, vol. 5, p. e006642, 2015.
R. McCarney, Fisher, P., and van Haselen, R., Accruing large numbers of patients in primary care trials by retrospective recruitment methods, Complement Ther Med, vol. 10, pp. 63-8, 2002.
A. M. Gallagher, Dedman, D., Padmanabhan, S., Leufkens, H. G. M., and de Vries, F., The accuracy of date of death recording in the Clinical Practice Research Datalink GOLD database in England compared with the Office for National Statistics death registrations, Pharmacoepidemiol Drug Saf, 2019.
I. Nazareth, King, M., Haines, A., Rangel, L., and Myers, S., Accuracy of diagnosis of psychosis on general practice computer system, Bmj, vol. 307, pp. 32-4, 1993.
C. Becker, Jick, S. S., and Meier, C. R., ACE inhibitor use and risk of cataract: a case-control analysis, Br J Ophthalmol, 2019.
J. A. Kaye, Myers, M. W., and Jick, H., Acetaminophen and the risk of renal and bladder cancer in the general practice research database, Epidemiology, vol. 12, pp. 690-4, 2001.
J. Dawson, Fulton, R., McInnes, G. T., Morton, R., Morrison, D., Padmanabhan, S., Hewitt, J., Meredith, P., Muir, S., Dominiczak, A. F., and Walters, M. R., Acetaminophen use and change in blood pressure in a hypertensive population, J Hypertens, vol. 31, pp. 1485-90; discussion 1490, 2013.
I. Tamimi, Nicolau, B., Eimar, H., S. Madathil, A., Kezouh, A., Karp, I., and Tamimi, F., Acetylcholinesterase inhibitors and the risk of osteoporotic fractures: nested case-control study, Osteoporos Int, vol. 29, pp. 849-857, 2018.
J. Spoendlin, Meier, C., Jick, S. S., and Meier, C. R., Achilles or biceps tendon rupture in women and men with type 2 diabetes: A population-based case-control study, J Diabetes Complications, vol. 30, pp. 903-9, 2016.
T. Khan, Alvand, A., Prieto-Alhambra, D., Culliford, D. J., Judge, A., Jackson, W. F., Scammell, B. E., Arden, N. K., and Price, A. J., ACL and meniscal injuries increase the risk of primary total knee replacement for osteoarthritis: a matched case-control study using the Clinical Practice Research Datalink (CPRD), Br J Sports Med, 2018.
F. J. de Abajo, Montero, D., Madurga, M., and Rodriguez, L. A. Garcia, Acute and clinically relevant drug-induced liver injury: a population based case-control study, Br J Clin Pharmacol, vol. 58, pp. 71-80, 2004.
L. A. Garcia Rodriguez, Ruigomez, A., and Panes, J., Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease, Gastroenterology, vol. 130, pp. 1588-94, 2006.
K. E. Mansfield, Douglas, I. J., Nitsch, D., Thomas, S. L., Smeeth, L., and Tomlinson, L. A., Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis, Clin Epidemiol, vol. 10, pp. 187-202, 2018.
M. F. Barakat, McDonald, H. I., Collier, T. J., Smeeth, L., Nitsch, D., and Quint, J. K., Acute kidney injury in stable COPD and at exacerbation, Int J Chron Obstruct Pulmon Dis, vol. 10, pp. 2067-77, 2015.
L. A. Garcia Rodriguez, Williams, R., Derby, L. E., Dean, A. D., and Jick, H., Acute liver injury associated with nonsteroidal anti-inflammatory drugs and the role of risk factors, Arch Intern Med, vol. 154, pp. 311-6, 1994.
C. Minassian, Thomas, S. L., Williams, D. J., Campbell, O., and Smeeth, L., Acute maternal infection and risk of pre-eclampsia: a population-based case-control study, PLoS One, vol. 8, p. e73047, 2013.
C. R. Meier, Jick, S. S., Derby, L. E., Vasilakis, C., and Jick, H., Acute respiratory-tract infections and risk of first-time acute myocardial infarction, Lancet, vol. 351, pp. 1467-71, 1998.
N. F. Khan, Perera, R., Harper, S., and Rose, P. W., Adaptation and validation of the Charlson Index for Read/OXMIS coded databases, BMC Fam Pract, vol. 11, p. 1, 2010.
A. J. Hire, Ashcroft, D. M., Springate, D. A., and Steinke, D. T., ADHD in the United Kingdom: Regional and Socioeconomic Variations in Incidence Rates Amongst Children and Adolescents (2004-2013), J Atten Disord, vol. 22, pp. 134-142, 2018.
M. Schmidt, Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sorensen, H. T., Smeeth, L., and Tomlinson, L. A., Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study, BMJ Open, vol. 7, p. e012818, 2017.
B. Hayhoe, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Bottle, A., Adherence to guidelines in management of symptoms suggestive of heart failure in primary care, Heart, 2018.
K. D. Johnson, Lu, X., and Zhang, D., Adherence to hepatitis A and hepatitis B multi-dose vaccination schedules among adults in the United Kingdom: a retrospective cohort study, BMC Public Health, vol. 19, p. 404, 2019.
K. Jameson, D'Oca, K., Murray-Thomas, T., O'Regan, C., and Leigh, P., Adherence to Nice Guidance For Initiating Glp-1 Mimetics Among Patients With Type 2 Diabetes In Primary Care In England And Wales - An Evaluation Using The Clinical Practice Research Datalink (Cprd), Value Health, vol. 17, p. A362, 2014.
K. Jameson, D'Oca, K., Leigh, P., and Murray-Thomas, T., Adherence to NICE guidance on glucagon-like peptide-1 receptor agonists among patients with type 2 diabetes mellitus: an evaluation using the Clinical Practice Research Datalink, Curr Med Res Opin, vol. 32, pp. 49-60, 2016.
A. J. Farmer, Rodgers, L. R., Lonergan, M., Shields, B., Weedon, M. N., Donnelly, L., Holman, R. R., Pearson, E. R., and Hattersley, A. T., Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database, Diabetes Care, vol. 39, pp. 258-263, 2016.
M. J. Crowther, Lambert, P. C., and Abrams, K. R., Adjusting for measurement error in baseline prognostic biomarkers included in a time-to-event analysis: a joint modelling approach, BMC Med Res Methodol, vol. 13, p. 146, 2013.
B. Numbere, Fleming, K. M., Walker, A., and Card, T. R., Adrenergic blockers and the risk for common solid cancers: a case-control study, Eur J Cancer Prev, vol. 26, pp. 86-93, 2017.
R. Hubbard and Venn, A., Adult height and cryptogenic fibrosing alveolitis: a case-control study using the UK general practice research database, Thorax, vol. 55, pp. 864-6, 2000.
S. B. Meropol, Chan, K. A., Chen, Z., Finkelstein, J. A., Hennessy, S., Lautenbach, E., Platt, R., Schech, S. D., Shatin, D., and Metlay, J. P., Adverse events associated with prolonged antibiotic use, Pharmacoepidemiol Drug Saf, vol. 17, pp. 523-32, 2008.
M. Bloechliger, Reinau, D., Spoendlin, J., Chang, S. C., Kuhlbusch, K., Heaney, L. G., Jick, S. S., and Meier, C. R., Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis, Respir Res, vol. 19, p. 75, 2018.
C. Tsang, Bottle, A., Majeed, A., and Aylin, P., Adverse events recorded in English primary care: observational study using the General Practice Research Database, Br J Gen Pract, vol. 63, pp. e534-42, 2013.
H. Carreira, Williams, R., Muller, M., Harewood, R., and Bhaskaran, K., Adverse mental health outcomes in breast cancer survivors compared to women who did not have cancer: systematic review protocol, Syst Rev, vol. 6, p. 162, 2017.
A. A. Sultan, West, J., Ban, L., Humes, D., Tata, L. J., Fleming, K. M., Nelson-Piercy, C., and Card, T., Adverse Pregnancy Outcomes Among Women with Inflammatory Bowel Disease: A Population-Based Study from England, Inflamm Bowel Dis, vol. 22, pp. 1621-30, 2016.
C. Martinez, Katholing, A., and Freedman, S. B., Adverse prognosis of incidentally detected ambulatory atrial fibrillation. A cohort study, Thromb Haemost, vol. 112, pp. 276-86, 2014.
T. Wrigley, Tinto, A., and Majeed, A., Age and sex specific antibiotic prescribing patterns in general practice in England and Wales, 1994 to 1998., Health Stat Q, vol. 14, pp. 14-20, 2002.
A. Majeed and Moser, K., Age- and sex-specific antibiotic prescribing patterns in general practice in England and Wales in 1996, Br J Gen Pract, vol. 49, pp. 735-6, 1999.
A. Majeed, Moser, K., and Maxwell, R., Age, sex and practice variations in the use of statins in general practice in England and Wales, J Public Health Med, vol. 22, pp. 275-9, 2000.
M. Ashworth, Charlton, J., Latinovic, R., and Gulliford, M., Age-related changes in consultations and antibiotic prescribing for acute respiratory infections, 1995-2000. Data from the UK General Practice Research Database, J Clin Pharm Ther, vol. 31, pp. 461-7, 2006.
[Page last reviewed 13 May 2019]