Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 November 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 192 pages)


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P. J. Peeters, Bazelier, M. T., Leufkens, H. G., Auvinen, A., van Staa, T. P., de Vries, F., and De Bruin, M. L., Insulin glargine use and breast cancer risk: Associations with cumulative exposure, Acta Oncol, vol. 55, pp. 851-8, 2016.
M. E. Goossens, Buntinx, F., Zeegers, M. P., Driessen, J. H., De Bruin, M. L., and de Vries, F., Influence of metformin intake on the risk of bladder cancer in type 2 diabetes patients, Br J Clin Pharmacol, vol. 80, pp. 1464-72, 2015.
J. M. Wijnands, van Durme, C. M., Driessen, J. H., Boonen, A., Klop, C., Leufkens, B., Cooper, C., Stehouwer, C. D., and de Vries, F., Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study, Medicine (Baltimore), vol. 94, p. e1358, 2015.
M. Simeonova, de Vries, F., Pouwels, S., Driessen, J. H. M., Leufkens, H. G. M., Cadarette, S. M., and Burden, A. M., Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK, Br J Clin Pharmacol, vol. 84, pp. 2551-2561, 2018.
R. Y. van der Velde, Wyers, C. E., Geusens, P., van den Bergh, J. P. W., de Vries, F., Cooper, C., van de Staa, T. P., and Harvey, N. C., Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older, Osteoporos Int, vol. 29, pp. 2469-2475, 2018.
M. Schuerch, Gasse, C., Robinson, N. J., Alvarez, Y., Walls, R., Mors, O., Christensen, J., Hesse, U., de Groot, M., Schlienger, R., Reynolds, R., Klungel, O., and de Vries, F., Impact of varying outcomes and definitions of suicidality on the associations of antiepileptic drugs and suicidality: comparisons from UK Clinical Practice Research Datalink (CPRD) and Danish national registries (DNR), Pharmacoepidemiol Drug Saf, vol. 25 Suppl 1, pp. 142-55, 2016.
J. T. H. Nielen, Dagnelie, P. C., Boonen, A., Klungel, O., van den Bemt, B., and de Vries, F., Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink, Diabetes Res Clin Pract, vol. 148, pp. 240-248, 2019.
A. M. Gallagher, Williams, T., Leufkens, H. G., and de Vries, F., The Impact of the Choice of Data Source in Record Linkage Studies Estimating Mortality in Venous Thromboembolism, PLoS One, vol. 11, p. e0148349, 2016.
J. T. Nielen, van den Bemt, B. J., Boonen, A., Dagnelie, P. C., Emans, P. J., Veldhorst, N., Lalmohamed, A., van Staa, T. P., and de Vries, F., Identification of antithrombotic drugs related to total joint replacement using anonymised free-text notes: a search strategy in the Clinical Practice Research Datalink, BMJ Open, vol. 5, p. e009017, 2015.
C. Huerta, Abbing-Karahagopian, V., Requena, G., Oliva, B., Alvarez, Y., Gardarsdottir, H., Miret, M., Schneider, C., Gil, M., Souverein, P. C., De Bruin, M. L., Slattery, J., de Groot, M. C., Hesse, U., Rottenkolber, M., Schmiedl, S., Montero, D., Bate, A., Ruigomez, A., Garcia-Rodriguez, L. A., Johansson, S., de Vries, F., Schlienger, R. G., Reynolds, R. F., Klungel, O. H., and de Abajo, F. J., Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project, Pharmacoepidemiol Drug Saf, vol. 25 Suppl 1, pp. 56-65, 2016.
R. J. Moon, Harvey, N. C., Curtis, E. M., de Vries, F., Van Staa, T., and Cooper, C., Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom, Bone, vol. 85, pp. 9-14, 2016.
C. Klop, van Staa, T. P., Cooper, C., Harvey, N. C., and de Vries, F., The epidemiology of mortality after fracture in England: variation by age, sex, time, geographic location, and ethnicity, Osteoporos Int, vol. 28, pp. 161-168, 2017.
E. M. Curtis, van der Velde, R., Moon, R. J., van den Bergh, J. P., Geusens, P., de Vries, F., van Staa, T. P., Cooper, C., and Harvey, N. C., Epidemiology of fractures in the United Kingdom 1988-2012: Variation with age, sex, geography, ethnicity and socioeconomic status, Bone, vol. 87, pp. 19-26, 2016.
C. Stolwijk, Essers, I., van Tubergen, A., Boonen, A., Bazelier, M. T., De Bruin, M. L., and de Vries, F., The epidemiology of extra-articular manifestations in ankylosing spondylitis: a population-based matched cohort study, Ann Rheum Dis, vol. 74, pp. 1373-8, 2015.
I. E. Bultink, Harvey, N. C., Lalmohamed, A., Cooper, C., Lems, W. F., van Staa, T. P., and de Vries, F., Elevated risk of clinical fractures and associated risk factors in patients with systemic lupus erythematosus versus matched controls: a population-based study in the United Kingdom, Osteoporos Int, vol. 25, pp. 1275-83, 2014.
G. Wallace, Judge, A., Prieto-Alhambra, D., de Vries, F., Arden, N. K., and Cooper, C., The effect of body mass index on the risk of post-operative complications during the 6 months following total hip replacement or total knee replacement surgery, Osteoarthritis Cartilage, vol. 22, pp. 918-27, 2014.
F. de Vries, Setakis, E., and van Staa, T. P., Concomitant use of ibuprofen and paracetamol and the risk of major clinical safety outcomes, Br J Clin Pharmacol, vol. 70, pp. 429-38, 2010.
R. G. de Jong, Gallagher, A. M., Herrett, E., Masclee, A. A., Janssen-Heijnen, M. L., and de Vries, F., Comparability of the age and sex distribution of the UK Clinical Practice Research Datalink and the total Dutch population, Pharmacoepidemiol Drug Saf, vol. 25, pp. 1460-1464, 2016.
den C. Heijer, Hoebe, C., Driessen, J. H., Wolffs, P., van den Broek, I., Hoenderboom, B., Williams, R., de Vries, F., and Dukers-Muijrers, N., Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients, Clinical Infectious Diseases, 2019.
A. Lalmohamed, Bazelier, M. T., van Staa, T. P., Uitdehaag, B. M., Leufkens, H. G., de Boer, A., and de Vries, F., Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study, Eur J Neurol, vol. 19, pp. 1007-14, 2012.
R. Williams, de Vries, F., Kothny, W., Serban, C., Lopez-Leon, S., Chu, C., and Schlienger, R., Cardiovascular safety of vildagliptin in patients with type 2 diabetes: A European multi-database, non-interventional post-authorization safety study, Diabetes Obes Metab, vol. 19, pp. 1473-1478, 2017.
A. But, De Bruin, M. L., Bazelier, M. T., Hjellvik, V., Andersen, M., Auvinen, A., Starup-Linde, J., Schmidt, M. K., Furu, K., de Vries, F., Karlstad, O., Ekstrom, N., and Haukka, J., Cancer risk among insulin users: comparing analogues with human insulin in the CARING five-country cohort study, Diabetologia, vol. 60, pp. 1691-1703, 2017.
R. Williams, van Staa, T. P., Gallagher, A. M., Hammad, T., Leufkens, H. G. M., and de Vries, F., Cancer recording in patients with and without type 2 diabetes in the Clinical Practice Research Datalink primary care data and linked hospital admission data: a cohort study, BMJ Open, vol. 8, p. e020827, 2018.
V. Abbing-Karahagopian, Kurz, X., de Vries, F., van Staa, T. P., Alvarez, Y., Hesse, U., Hasford, J., Dijk, L., de Abajo, F. J., Weil, J. G., Grimaldi-Bensouda, L., Egberts, A. C., Reynolds, R. F., and Klungel, O. H., Bridging differences in outcomes of pharmacoepidemiological studies: design and first results of the PROTECT project, Curr Clin Pharmacol, vol. 9, pp. 130-8, 2014.
J. H. Driessen, Henry, R. M., van Onzenoort, H. A., Lalmohamed, A., Burden, A. M., Prieto-Alhambra, D., Neef, C., Leufkens, H. G., and de Vries, F., Bone fracture risk is not associated with the use of glucagon-like peptide-1 receptor agonists: a population-based cohort analysis, Calcif Tissue Int, vol. 97, pp. 104-12, 2015.
O. A. Oshagbemi, Franssen, F. M. E., Braeken, D. C. W., Henskens, Y., Wouters, E. F. M., van der Zee, A. H. Maitlan, Burden, A. M., and de Vries, F., Blood eosinophilia, use of inhaled corticosteroids, and risk of COPD exacerbations and mortality, Pharmacoepidemiol Drug Saf, vol. 27, pp. 1191-1199, 2018.
O. A. Oshagbemi, Franssen, F. M. E., van Kraaij, S., Braeken, D. C. W., Wouters, E. F. M., van der Zee, A. H. Maitlan, Driessen, J. H. M., and de Vries, F., Blood Eosinophil Counts, Withdrawal of Inhaled Corticosteroids and Risk of COPD Exacerbations and Mortality in the Clinical Practice Research Datalink (CPRD), Copd, pp. 1-8, 2019.
R. Williams, Kothny, W., Serban, C., Lopez-Leon, S., de Vries, F., and Schlienger, R., Association between vildagliptin and risk of angioedema, foot ulcers, skin lesions, hepatic toxicity, and serious infections in patients with type 2 diabetes mellitus: A European multidatabase, noninterventional, postauthorization safety study, Endocrinol Diabetes Metab, vol. 2, p. e00084, 2019.
C. Klop, Gibson-Smith, D., Elders, P. J., Welsing, P. M., Leufkens, H. G., Harvey, N. C., Bijlsma, J. W., van Staa, T. P., and de Vries, F., Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010, Osteoporos Int, vol. 26, pp. 1919-28, 2015.
V. Abbing-Karahagopian, Huerta, C., Souverein, P. C., de Abajo, F., Leufkens, H. G., Slattery, J., Alvarez, Y., Miret, M., Gil, M., Oliva, B., Hesse, U., Requena, G., de Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlienger, R. G., de Groot, M. C., Klungel, O. H., van Staa, T. P., van Dijk, L., Egberts, A. C., Gardarsdottir, H., and De Bruin, M. L., Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications, Eur J Clin Pharmacol, vol. 70, pp. 849-57, 2014.
I. Essers, Stolwijk, C., Boonen, A., De Bruin, M. L., Bazelier, M. T., de Vries, F., and van Tubergen, A., Ankylosing spondylitis and risk of ischaemic heart disease: a population-based cohort study, Ann Rheum Dis, vol. 75, pp. 203-9, 2016.
A. M. Gallagher, Dedman, D., Padmanabhan, S., Leufkens, H. G. M., and de Vries, F., The accuracy of date of death recording in the Clinical Practice Research Datalink GOLD database in England compared with the Office for National Statistics death registrations, Pharmacoepidemiol Drug Saf, 2019.
[Page last reviewed 4 November 2019]