Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 June 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 183 pages)


Export 2252 results:
Author Title Type [ Year(Asc)]
J. van Dalem, Brouwers, M., Stehouwer, C. D. A., Krings, A., Klungel, O. H., Driessen, J. H. M., de Vries, F., and Burden, A. M., Risk of a first-ever acute myocardial infarction and all-cause mortality with sulphonylurea treatment: A population-based cohort study, Diabetes Obes Metab, vol. 20, pp. 1056-1060, 2018.
H. Ahmed, Farewell, D., Francis, N. A., Paranjothy, S., and Butler, C. C., Risk of adverse outcomes following urinary tract infection in older people with renal impairment: Retrospective cohort study using linked health record data, PLoS Med, vol. 15, p. e1002652, 2018.
M. Roughley, Sultan, A. A., Clarson, L., Muller, S., Whittle, R., Belcher, J., Mallen, C. D., and Roddy, E., Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study, Arthritis Res Ther, vol. 20, p. 243, 2018.
Z. Paskins, Whittle, R., Sultan, A. A., Muller, S., Blagojevic-Bucknall, M., Helliwell, T., Hider, S., Roddy, E., and Mallen, C., Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study, BMC Med, vol. 16, p. 4, 2018.
A. A. Sultan, Whittle, R., Muller, S., Roddy, E., Mallen, C. D., Bucknall, M., Helliwell, T., Hider, S., and Paskins, Z., Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy, Cmaj, vol. 190, pp. E581-e587, 2018.
Z. Paskins, Whittle, R., A. Sultan, A., Muller, S., Blagojevic-Bucknall, M., Helliwell, T., Packham, J., Hider, S., Roddy, E., and Mallen, C., Risk of fragility fracture among patients with late-onset psoriasis: a UK population-based study, Osteoporos Int, vol. 29, pp. 1659-1664, 2018.
J. M. Gamble, Donnan, J. R., Chibrikov, E., Twells, L. K., Midodzi, W. K., and Majumdar, S. R., The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study, Diabetes Res Clin Pract, vol. 136, pp. 159-167, 2018.
S. Erridge, Moussa, O. M., Ziprin, P., Darzi, A., and Purkayastha, S., Risk of GERD-Related Disorders in Obese Patients on PPI Therapy: a Population Analysis, Obes Surg, vol. 28, pp. 2796-2803, 2018.
M. Blagojevic-Bucknall, Mallen, C., Muller, S., Hayward, R., West, S., Choi, H., and Roddy, E., The risk of gout among patients with sleep apnea: a matched cohort study, Arthritis Rheumatol, 2018.
T. Burkard, Hugle, T., Layton, J. B., Glynn, R. J., Bloechliger, M., Frey, N., Jick, S. S., Meier, C. R., and Spoendlin, J., Risk of Incident Osteoarthritis of the Hand in Statin Initiators: A Sequential Cohort Study, Arthritis Care Res (Hoboken), vol. 70, pp. 1795-1805, 2018.
Y. Wang, Pfeiffer, R. M., Alsaggaf, R., Meeraus, W., Gage, J. C., Anderson, L. A., Bremer, R. C., Nikolenko, N., Lochmuller, H., Greene, M. H., and Gadalla, S. M., Risk of skin cancer among patients with myotonic dystrophy type 1 based on primary care physician data from the U.K. Clinical Practice Research Datalink, Int J Cancer, vol. 142, pp. 1174-1181, 2018.
R. Charlton, Green, A., Shaddick, G., Snowball, J., Nightingale, A., Tillett, W., Smith, C., and McHugh, N., Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: a population-based cohort study, Rheumatology (Oxford), 2018.
H. C. Gorton, Webb, R. T., Carr, M. J., DelPozo-Banos, M., John, A., and Ashcroft, D. M., Risk of Unnatural Mortality in People With Epilepsy, JAMA Neurol, vol. 75, pp. 929-938, 2018.
R. Charlton, Green, A., Shaddick, G., Snowball, J., Nightingale, A., Tillett, W., Smith, C. H., and McHugh, N., Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population-based cohort study, Ann Rheum Dis, vol. 77, pp. 277-280, 2018.
E. Martin-Merino, Petersen, I., Hawley, S., Alvarez-Gutierrez, A., Khalid, S., Llorente-Garcia, A., Delmestri, A., Javaid, M. K., van Staa, T. P., Judge, A., Cooper, C., and Prieto-Alhambra, D., Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK, Osteoporos Int, vol. 29, pp. 467-478, 2018.
T. P. C. Chu, Grainge, M. J., and Card, T. R., The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity, Aliment Pharmacol Ther, vol. 48, pp. 1099-1108, 2018.
Y. Vinogradova, Coupland, C., Hill, T., and Hippisley-Cox, J., Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care, Bmj, vol. 362, p. k2505, 2018.
A. Bottle, Kim, D., Aylin, P., Cowie, M. R., Majeed, A., and Hayhoe, B., Routes to diagnosis of heart failure: observational study using linked data in England, Heart, vol. 104, pp. 600-605, 2018.
P. Bryan, Seabroke, S., Wong, J., Donegan, K., Webb, E., Goldsmith, C., Vipond, C., and Feavers, I., Safety of multicomponent meningococcal group B vaccine (4CMenB) in routine infant immunisation in the UK: a prospective surveillance study, Lancet Child Adolesc Health, vol. 2, pp. 395-403, 2018.
S. Muller, Hider, S., Machin, A., Stack, R., Hayward, R. A., Raza, K., and Mallen, C., Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink, Semin Arthritis Rheum, 2018.
E. A. Shephard and Hamilton, W. T., Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records, Br J Gen Pract, vol. 68, pp. e559-e565, 2018.
J. Busby, Mills, K., Zhang, S. D., Liberante, F. G., and Cardwell, C. R., Selective serotonin reuptake inhibitor use and breast cancer survival: a population-based cohort study, Breast Cancer Res, vol. 20, p. 4, 2018.
C. Morgan, Webb, R. T., Carr, M. J., Kontopantelis, E., Chew-Graham, C. A., Kapur, N., and Ashcroft, D. M., Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death, Lancet Psychiatry, vol. 5, pp. 905-912, 2018.
H. Furuland, McEwan, P., Evans, M., Linde, C., Ayoubkhani, D., Bakhai, A., Palaka, E., Bennett, H., and Qin, L., Serum potassium as a predictor of adverse clinical outcomes in patients with chronic kidney disease: new risk equations using the UK clinical practice research datalink, BMC Nephrol, vol. 19, p. 211, 2018.
R. J. Silverwood, Forbes, H. J., Abuabara, K., Ascott, A., Schmidt, M., Schmidt, S. A. J., Smeeth, L., and Langan, S. M., Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study, Bmj, vol. 361, p. k1786, 2018.
M. Iwagami, Mansfield, K. E., Hayes, J. F., Walters, K., Osborn, D. P., Smeeth, L., Nitsch, D., and Tomlinson, L. A., Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom, Clin Epidemiol, vol. 10, pp. 421-429, 2018.
J. M. Dennis, Henley, W. E., Weedon, M. N., Lonergan, M., Rodgers, L. R., Jones, A. G., Hamilton, W. T., Sattar, N., Janmohamed, S., Holman, R. R., Pearson, E. R., Shields, B. M., and Hattersley, A. T., Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data, Diabetes Care, vol. 41, pp. 1844-1853, 2018.
S. Weir, Samnaliev, M., Kuo, T. C., Tierney, T. S., S. Autiero, W., Taylor, R. S., and Schrag, A., Short- and long-term cost and utilization of health care resources in Parkinson's disease in the UK, Mov Disord, vol. 33, pp. 974-981, 2018.
E. Kontopantelis, Stevens, R. J., Helms, P. J., Edwards, D., Doran, T., and Ashcroft, D. M., Spatial distribution of clinical computer systems in primary care in England in 2016 and implications for primary care electronic medical record databases: a cross-sectional population study, BMJ Open, vol. 8, p. e020738, 2018.
Z. Liu, Alsaggaf, R., McGlynn, K. A., Anderson, L. A., Tsai, H. T., Zhu, B., Zhu, Y., Mbulaiteye, S. M., Gadalla, S. M., and Koshiol, J., Statin use and reduced risk of biliary tract cancers in the UK Clinical Practice Research Datalink, Gut, 2018.
A. D. Spence, Busby, J., Hughes, C. M., Johnston, B. T., Coleman, H. G., and Cardwell, C. R., Statin use and survival in patients with gastric cancer in two independent population-based cohorts, Pharmacoepidemiol Drug Saf, 2018.
K. Chidwick, Strongman, H., Matthews, A., Stanway, S., Lyon, A. R., Smeeth, L., and Bhaskaran, K., Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink, BMC Cancer, vol. 18, p. 1018, 2018.
A. Pate, Barrowman, M., Webb, D., Pimenta, J. M., Davis, K. J., Williams, R., Van Staa, T., and Sperrin, M., Study investigating the generalisability of a COPD trial based in primary care (Salford Lung Study) and the presence of a Hawthorne effect, BMJ Open Respir Res, vol. 5, p. e000339, 2018.
O. Yu, Azoulay, L., Yin, H., Filion, K. B., and Suissa, S., Sulfonylureas as Initial Treatment for Type 2 Diabetes and the Risk of Severe Hypoglycemia, Am J Med, vol. 131, pp. 317.e11-317.e22, 2018.
A. Douros, Dell'Aniello, S., Yu, O. H. Y., Filion, K. B., Azoulay, L., and Suissa, S., Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study, Bmj, vol. 362, p. k2693, 2018.
R. M. Joseph, Soames, J., Wright, M., Sultana, K., van Staa, T. P., and Dixon, W. G., Supplementing electronic health records through sample collection and patient diaries: A study set within a primary care research database, Pharmacoepidemiol Drug Saf, vol. 27, pp. 239-242, 2018.
N. Conrad, Judge, A., Tran, J., Mohseni, H., Hedgecott, D., Crespillo, A. P., Allison, M., Hemingway, H., Cleland, J. G., McMurray, J. J. V., and Rahimi, K., Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals, Lancet, vol. 391, pp. 572-580, 2018.
J. W. O'Sullivan, Stevens, S., Hobbs, F. D. R., Salisbury, C., Little, P., Goldacre, B., Bankhead, C., Aronson, J. K., Perera, R., and Heneghan, C., Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests, Bmj, vol. 363, p. k4666, 2018.
C. Martinez, Katholing, A., Folkerts, K., and Rietbrock, S., Thirteen-year trend in the persistence with vitamin K antagonists for venous thromboembolism in the UK: a cohort study, Curr Med Res Opin, vol. 34, pp. 1985-1990, 2018.
U. Desai, Kirson, N. Y., Kim, J., Khunti, K., King, S., Trieschman, E., Hellstern, M., Hunt, P. R., and Mukherjee, J., Time to Treatment Intensification After Monotherapy Failure and Its Association With Subsequent Glycemic Control Among 93,515 Patients With Type 2 Diabetes, Diabetes Care, vol. 41, pp. 2096-2104, 2018.
H. J. Curtis, Dennis, J. M., Shields, B. M., Walker, A. J., Bacon, S., Hattersley, A. T., Jones, A. G., and Goldacre, B., Time trends and geographical variation in prescribing of drugs for diabetes in England from 1998 to 2017, Diabetes Obes Metab, vol. 20, pp. 2159-2168, 2018.
S. M. Grandi, Reynier, P., Platt, R. W., Basso, O., and Filion, K. B., The timing of onset of hypertensive disorders in pregnancy and the risk of incident hypertension and cardiovascular disease, Int J Cardiol, vol. 270, pp. 273-275, 2018.
J. A. Hirst, Farmer, A. J., Smith, M. C., and Stevens, R. J., Timings for HbA1c testing in people with diabetes are associated with incentive payments: an analysis of UK primary care data, Diabet Med, 2018.
J. Charlton, Ravindrarajah, R., Hamada, S., Jackson, S. H., and Gulliford, M. C., Trajectory of Total Cholesterol in the Last Years of Life Over Age 80 Years: Cohort Study of 99,758 Participants, J Gerontol A Biol Sci Med Sci, vol. 73, pp. 1083-1089, 2018.
J. Gordon, McEwan, P., Idris, I., Evans, M., and Puelles, J., Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study, BMJ Open Diabetes Res Care, vol. 6, p. e000512, 2018.
I. Idris, Peng, X., He, X., Liu, D., Balogh, E., Kaushik, P., and van Brunt, K., The Trend of High-Dose Insulin Usage Among Patients with Diabetes in the UK: A Retrospective Study, Diabetes Ther, vol. 9, pp. 2245-2257, 2018.
E. Burn, Edwards, C. J., Murray, D. W., Silman, A., Cooper, C., Arden, N. K., Pinedo-Villanueva, R., and Prieto-Alhambra, D., Trends and determinants of length of stay and hospital reimbursement following knee and hip replacement: evidence from linked primary care and NHS hospital records from 1997 to 2014, BMJ Open, vol. 8, p. e019146, 2018.
V. W. Zhong, Juhaeri, J., and Mayer-Davis, E. J., Trends in Hospital Admission for Diabetic Ketoacidosis in Adults With Type 1 and Type 2 Diabetes in England, 1998-2013: A Retrospective Cohort Study, Diabetes Care, vol. 41, pp. 1870-1877, 2018.
O. A. Oshagbemi, Keene, S. J., Driessen, J. H. M., Jordan, R., Wouters, E. F. M., de Boer, A., de Vries, F., and Franssen, F. M. E., Trends in moderate and severe exacerbations among COPD patients in the UK from 2005 to 2013, Respir Med, vol. 144, pp. 1-6, 2018.
C. L. Burton, Chen, Y., Chesterton, L. S., and van der Windt, D. A., Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records, BMJ Open, vol. 8, p. e020166, 2018.
[Page last reviewed 6 June 2019]