Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,000 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 April 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2216 results:
Author Title Type [ Year(Asc)]
U. Desai, Kirson, N. Y., Kim, J., Khunti, K., King, S., Trieschman, E., Hellstern, M., Hunt, P. R., and Mukherjee, J., Time to Treatment Intensification After Monotherapy Failure and Its Association With Subsequent Glycemic Control Among 93,515 Patients With Type 2 Diabetes, Diabetes Care, vol. 41, pp. 2096-2104, 2018.
H. J. Curtis, Dennis, J. M., Shields, B. M., Walker, A. J., Bacon, S., Hattersley, A. T., Jones, A. G., and Goldacre, B., Time trends and geographical variation in prescribing of drugs for diabetes in England from 1998 to 2017, Diabetes Obes Metab, vol. 20, pp. 2159-2168, 2018.
S. M. Grandi, Reynier, P., Platt, R. W., Basso, O., and Filion, K. B., The timing of onset of hypertensive disorders in pregnancy and the risk of incident hypertension and cardiovascular disease, Int J Cardiol, vol. 270, pp. 273-275, 2018.
J. A. Hirst, Farmer, A. J., Smith, M. C., and Stevens, R. J., Timings for HbA1c testing in people with diabetes are associated with incentive payments: an analysis of UK primary care data, Diabet Med, 2018.
J. Charlton, Ravindrarajah, R., Hamada, S., Jackson, S. H., and Gulliford, M. C., Trajectory of Total Cholesterol in the Last Years of Life Over Age 80 Years: Cohort Study of 99,758 Participants, J Gerontol A Biol Sci Med Sci, vol. 73, pp. 1083-1089, 2018.
J. Gordon, McEwan, P., Idris, I., Evans, M., and Puelles, J., Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study, BMJ Open Diabetes Res Care, vol. 6, p. e000512, 2018.
I. Idris, Peng, X., He, X., Liu, D., Balogh, E., Kaushik, P., and van Brunt, K., The Trend of High-Dose Insulin Usage Among Patients with Diabetes in the UK: A Retrospective Study, Diabetes Ther, vol. 9, pp. 2245-2257, 2018.
E. Burn, Edwards, C. J., Murray, D. W., Silman, A., Cooper, C., Arden, N. K., Pinedo-Villanueva, R., and Prieto-Alhambra, D., Trends and determinants of length of stay and hospital reimbursement following knee and hip replacement: evidence from linked primary care and NHS hospital records from 1997 to 2014, BMJ Open, vol. 8, p. e019146, 2018.
V. W. Zhong, Juhaeri, J., and Mayer-Davis, E. J., Trends in Hospital Admission for Diabetic Ketoacidosis in Adults With Type 1 and Type 2 Diabetes in England, 1998-2013: A Retrospective Cohort Study, Diabetes Care, vol. 41, pp. 1870-1877, 2018.
O. A. Oshagbemi, Keene, S. J., Driessen, J. H. M., Jordan, R., Wouters, E. F. M., de Boer, A., de Vries, F., and Franssen, F. M. E., Trends in moderate and severe exacerbations among COPD patients in the UK from 2005 to 2013, Respir Med, vol. 144, pp. 1-6, 2018.
C. L. Burton, Chen, Y., Chesterton, L. S., and van der Windt, D. A., Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records, BMJ Open, vol. 8, p. e020166, 2018.
E. Crellin, Mansfield, K. E., Leyrat, C., Nitsch, D., Douglas, I. J., Root, A., Williamson, E., Smeeth, L., and Tomlinson, L. A., Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study, Bmj, vol. 360, p. k341, 2018.
L. McDonald, Sammon, C. J., Samnaliev, M., and Ramagopalan, S., Under-recording of hospital bleeding events in UK primary care: a linked Clinical Practice Research Datalink and Hospital Episode Statistics study, Clin Epidemiol, vol. 10, pp. 1155-1168, 2018.
D. Yu, Jordan, K. P., and Peat, G., Underrecording of osteoarthritis in United Kingdom primary care electronic health record data, Clin Epidemiol, vol. 10, pp. 1195-1201, 2018.
F. Ahmadizar, Souverein, P., de Boer, A., and van der Zee, A. H. Maitlan, Undertreatment of hypertension and hypercholesterolaemia in children and adolescents with type 1 diabetes: long-term follow-up on time trends in the occurrence of cardiovascular disease, risk factors and medications use, Br J Clin Pharmacol, vol. 84, pp. 776-785, 2018.
C. F. Kuo, Chou, I. J., See, L. C., Chen, J. S., Yu, K. H., Luo, S. F., Hsieh, A. H., Zhang, W., and Doherty, M., Urate-lowering treatment and risk of total joint replacement in patients with gout, Rheumatology (Oxford), vol. 57, pp. 2129-2139, 2018.
A. Douros, Abrahami, D., Yin, H., Yu, O. H. Y., Renoux, C., Hudson, M., and Azoulay, L., Use of Dipeptidyl Peptidase-4 Inhibitors and New-onset Rheumatoid Arthritis in Patients with Type 2 Diabetes, Epidemiology, vol. 29, pp. 904-912, 2018.
A. Keyany, Nielen, J. T. H., Souverein, P. C., de Vries, F., and van den Bemt, B., Use of parenteral glucocorticoids and the risk of new onset type 2 diabetes mellitus: A case-control study, Diabetes Res Clin Pract, vol. 139, pp. 100-106, 2018.
P. Tammes, Sartini, C., Preston, I., Hay, A. D., Lasserson, D., and Morris, R. W., Use of primary care data to predict those most vulnerable to cold weather: a case-crossover analysis, Br J Gen Pract, vol. 68, pp. e146-e156, 2018.
A. Tran-Duy, Connell, N. J., Vanmolkot, F. H., Souverein, P. C., de Wit, N. J., Stehouwer, C. D. A., Hoes, A. W., de Vries, F., and de Boer, A., Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study, J Intern Med, 2018.
J. G. Kuiper, van Herk-Sukel, M. P. P., Castellsague, J., Pottegard, A., Berglind, I. A., Dedman, D., Gutierrez, L., Calingaert, B., Hallas, J., Sundstrom, A., Gallagher, A. M., Kaye, J. A., Pardo, C., Rothman, K. J., and Perez-Gutthann, S., Use of Topical Tacrolimus and Topical Pimecrolimus in Four European Countries: A Multicentre Database Cohort Study, Drugs Real World Outcomes, 2018.
S. S. Zghebi, Rutter, M. K., Ashcroft, D. M., Salisbury, C., Mallen, C., Chew-Graham, C. A., Reeves, D., van Marwijk, H., Qureshi, N., Weng, S., Peek, N., Planner, C., Nowakowska, M., Mamas, M., and Kontopantelis, E., Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design, BMJ Open, vol. 8, p. e020926, 2018.
S. L. Stevens, McManus, R. J., and Stevens, R. J., The utility of long-term blood pressure variability for cardiovascular risk prediction in primary care, J Hypertens, 2018.
A. V. Margulis, Fortuny, J., Kaye, J. A., Calingaert, B., Reynolds, M., Plana, E., McQuay, L. J., Atsma, W. J., Franks, B., de Vogel, S., Perez-Gutthann, S., and Arana, A., Validation of Cancer Cases Using Primary Care, Cancer Registry, and Hospitalization Data in the United Kingdom, Epidemiology, vol. 29, pp. 308-313, 2018.
R. J. Ferguson, Prieto-Alhambra, D., Walker, C., Yu, D., Valderas, J. M., Judge, A., Griffiths, J., Jordan, K. P., Peat, G., Glyn-Jones, S., and Silman, A. J., Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, 2018.
C. J. Crooks, West, J., and Jepsen, P., A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink, Clin Epidemiol, vol. 10, pp. 107-120, 2018.
A. V. Margulis, Fortuny, J., Kaye, J. A., Calingaert, B., Reynolds, M., Plana, E., McQuay, L. J., Atsma, W. J., Franks, B., de Vogel, S., Perez-Gutthann, S., and Arana, A., Value of Free-text Comments for Validating Cancer Cases Using Primary-care Data in the United Kingdom, Epidemiology, vol. 29, pp. e41-e42, 2018.
A. Arana, Margulis, A. V., McQuay, L. J., Ziemiecki, R., Bartsch, J. L., Rothman, K. J., Franks, B., D'Silva, M., Appenteng, K., Varas-Lorenzo, C., and Perez-Gutthann, S., Variation in Cardiovascular Risk Related to Individual Antimuscarinic Drugs Used to Treat Overactive Bladder: A UK Cohort Study, Pharmacotherapy, vol. 38, pp. 628-637, 2018.
V. M. Walker, Davies, N. M., Kehoe, P. G., and Martin, R. M., What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink, Alzheimers Res Ther, vol. 10, p. 51, 2018.
A. Jain, Walker, J. L., Mathur, R., Forbes, H. J., Langan, S. M., Smeeth, L., van Hoek, A. J., and Thomas, S. L., Zoster vaccination inequalities: A population based cohort study using linked data from the UK Clinical Practice Research Datalink, PLoS One, vol. 13, p. e0207183, 2018.
M. Schmidt, Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sorensen, H. T., Smeeth, L., and Tomlinson, L. A., Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study, BMJ Open, vol. 7, p. e012818, 2017.
B. Numbere, Fleming, K. M., Walker, A., and Card, T. R., Adrenergic blockers and the risk for common solid cancers: a case-control study, Eur J Cancer Prev, vol. 26, pp. 86-93, 2017.
H. Carreira, Williams, R., Muller, M., Harewood, R., and Bhaskaran, K., Adverse mental health outcomes in breast cancer survivors compared to women who did not have cancer: systematic review protocol, Syst Rev, vol. 6, p. 162, 2017.
D. Stewart, Han, L., Doran, T., and McCambridge, J., Alcohol consumption and all-cause mortality: an analysis of general practice database records for patients with long-term conditions, J Epidemiol Community Health, vol. 71, pp. 729-735, 2017.
R. Parisi, Webb, R. T., Carr, M. J., Moriarty, K. J., Kleyn, C. E., Griffiths, C. E. M., and Ashcroft, D. M., Alcohol-Related Mortality in Patients With Psoriasis: A Population-Based Cohort Study, JAMA Dermatol, vol. 153, pp. 1256-1262, 2017.
B. M. Hicks, Klil-Drori, A. J., Yin, H., Campeau, L., and Azoulay, L., Androgen Deprivation Therapy and the Risk of Anemia in Men with Prostate Cancer, Epidemiology, vol. 28, pp. 712-718, 2017.
F. Khosrow-Khavar, Rej, S., Yin, H., Aprikian, A., and Azoulay, L., Androgen Deprivation Therapy and the Risk of Dementia in Patients With Prostate Cancer, J Clin Oncol, vol. 35, pp. 201-207, 2017.
B. M. Hicks, Yin, H., Bladou, F., Ernst, P., and Azoulay, L., Androgen deprivation therapy for prostate cancer and the risk of hospitalisation for community-acquired pneumonia, Thorax, vol. 72, pp. 596-597, 2017.
S. J. Stocks, Kontopantelis, E., Webb, R. T., Avery, A. J., Burns, A., and Ashcroft, D. M., Antipsychotic Prescribing to Patients Diagnosed with Dementia Without a Diagnosis of Psychosis in the Context of National Guidance and Drug Safety Warnings: Longitudinal Study in UK General Practice, Drug Saf, vol. 40, pp. 679-692, 2017.
A. Leite, Andrews, N. J., and Thomas, S. L., Assessing recording delays in general practice records to inform near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD), Pharmacoepidemiol Drug Saf, vol. 26, pp. 437-445, 2017.
M. Z. Ankarfeldt, Thorsted, B. L., Groenwold, R. H., Adalsteinsson, E., Ali, M. S., and Klungel, O. H., Assessment of channeling bias among initiators of glucose-lowering drugs: A UK cohort study, Clin Epidemiol, vol. 9, pp. 19-30, 2017.
I. Barker, Steventon, A., and Deeny, S. R., Association between continuity of care in general practice and hospital admissions for ambulatory care sensitive conditions: cross sectional study of routinely collected, person level data, Bmj, vol. 356, p. j84, 2017.
R. Baker, Kendrick, D., Tata, L. J., and Orton, E., Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England, Inj Prev, vol. 23, pp. 396-402, 2017.
S. G. Bruderer, Meier, C. R., Jick, S. S., and Bodmer, M., The association between thyroid disorders and incident gout: population-based case-control study, Clin Epidemiol, vol. 9, pp. 205-215, 2017.
J. Browne, Edwards, D. A., Rhodes, K. M., Brimicombe, D. J., and Payne, R. A., Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study, BMJ Open, vol. 7, p. e012546, 2017.
H. B. Mehta, Mehta, V., and Goodwin, J. S., Association of Hypoglycemia With Subsequent Dementia in Older Patients With Type 2 Diabetes Mellitus, J Gerontol A Biol Sci Med Sci, vol. 72, pp. 1110-1116, 2017.
J. M. Gamble, Chibrikov, E., Twells, L. K., Midodzi, W. K., Young, S. W., MacDonald, D., and Majumdar, S. R., Association of insulin dosage with mortality or major adverse cardiovascular events: a retrospective cohort study, Lancet Diabetes Endocrinol, vol. 5, pp. 43-52, 2017.
C. Renoux, Vahey, S., Dell'Aniello, S., and Boivin, J. F., Association of Selective Serotonin Reuptake Inhibitors With the Risk for Spontaneous Intracranial Hemorrhage, JAMA Neurol, vol. 74, pp. 173-180, 2017.
C. Renoux, Dell'Aniello, S., Brenner, B., and Suissa, S., Bias from depletion of susceptibles: the example of hormone replacement therapy and the risk of venous thromboembolism, Pharmacoepidemiol Drug Saf, vol. 26, pp. 554-560, 2017.
S. J. Sinnott, Mansfield, K. E., Schmidt, M., Bhaskaran, K., Smeeth, L., Nitsch, D., and Tomlinson, L. A., Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study, BMJ Open, vol. 7, p. e018153, 2017.
[Page last reviewed 12 April 2019]